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Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZgene.[5][6]
Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.[6]
Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Critical Reviews in Biochemistry and Molecular Biology. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID7555018.
Hess J, Perez-Stable C, Wu GJ, Weir B, Tinoco I, Shen CK (July 1985). "End-to-end transcription of an Alu family repeat. A new type of polymerase-III-dependent terminator and its evolutionary implication". Journal of Molecular Biology. 184 (1): 7–21. doi:10.1016/0022-2836(85)90039-7. PMID2411938.
Aschauer H, Schäfer W, Sanguansermsri T, Braunitzer G (December 1981). "[Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains (author's transl)]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 362 (12): 1657–9. PMID6172357.
Aschauer H, Sanguansermsri T, Braunitzer G (August 1981). "[Human embryonic haemoglobins. The primary structure of the zeta chains (author's transl)]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 362 (8): 1159–62. PMID6179844.
Proudfoot NJ, Gil A, Maniatis T (December 1982). "The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene". Cell. 31 (3 Pt 2): 553–63. doi:10.1016/0092-8674(82)90311-7. PMID6297773. S2CID36907055.
Flint J, Thomas K, Micklem G, Raynham H, Clark K, Doggett NA, King A, Higgs DR (March 1997). "The relationship between chromosome structure and function at a human telomeric region". Nature Genetics. 15 (3): 252–7. doi:10.1038/ng0397-252. PMID9054936. S2CID20630444.
Luo HY, Liang XL, Frye C, Wonio M, Hankins GD, Chui DH, Alter BP (July 1999). "Embryonic hemoglobins are expressed in definitive cells". Blood. 94 (1): 359–61. doi:10.1182/blood.V94.1.359.413a29_359_361. PMID10381533.
Lau ET, Kwok YK, Chui DH, Wong HS, Luo HY, Tang MH (July 2001). "Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures". Prenatal Diagnosis. 21 (7): 529–39. doi:10.1002/pd.81. PMID11494285. S2CID11841129.
This page was last edited on 28 October 2022, at 16:10