Guanylate cyclase 2C

GUCY2C
Identifiers
Aliases	GUCY2C, DIAR6, GUC2C, MECIL, MUCIL, STAR, guanylate cyclase 2C, GC-C
External IDs	OMIM: 601330 MGI: 106903 HomoloGene: 3641 GeneCards: GUCY2C
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.3 Start 14,612,632 bp[1] End 14,696,599 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G1|6 66.67 cM Start 136,674,282 bp[2] End 136,758,763 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa rectum duodenum secondary oocyte appendix smooth muscle tissue monocyte islet of Langerhans body of pancreas skin of abdomen Top expressed in jejunum colon duodenum ileum intestinal villus lymph node islet of Langerhans secondary oocyte diencephalon crypt of lieberkuhn of small intestine More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase activity nucleotide binding GTP binding protein binding lyase activity phosphorus-oxygen lyase activity ATP binding toxic substance binding guanylate cyclase activity adenylate cyclase activity peptide receptor activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum guanylate cyclase complex, soluble plasma membrane Biological process intracellular signal transduction cyclic nucleotide biosynthetic process receptor guanylyl cyclase signaling pathway protein phosphorylation regulation of cell population proliferation response to toxic substance cGMP biosynthetic process digestion signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2984 14917 Ensembl ENSG00000070019 ENSMUSG00000042638 UniProt P25092 Q3UWA6 RefSeq (mRNA) NM_004963 NM_001127318 NM_145067 RefSeq (protein) NP_004954 NP_001120790 NP_659504 Location (UCSC) Chr 12: 14.61 – 14.7 Mb Chr 6: 136.67 – 136.76 Mb PubMed search [3] [4]
Wikidata
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Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.^[5][6]

Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain.^[7] The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.

Functions

GC-C is a key receptor for heat-stable enterotoxins that are responsible for acute secretory diarrhea.^[8] Heat-stable enterotoxins are produced by pathogens such as Escherichia coli. Knockout mice deficient in the GC-C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin. This demonstrates the specificity of the GC-C receptor.

In medicine

Guanylate cyclase 2C is the target of linaclotide and plecanatide, oligopeptide agonists used for the treatment of chronic constipation.

References

Further reading

External links

• GCC testing for colorectal cancer staging
• GC-C knock-out mice
• guanyl+cyclase-C+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This page was last edited on 29 January 2023, at 19:14