GUCY1A2

GUCY1A2

Identifiers

GUCY1A2, GC-SA2, GUC1A2, guanylate cyclase 1, soluble, alpha 2, guanylate cyclase 1 soluble subunit alpha 2

External IDs

OMIM: 601244 MGI: 2660877 HomoloGene: 47953 GeneCards: GUCY1A2

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q22.3	Start	106,674,019 bp^[1]
Band	11q22.3	End	107,018,476 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 A1	Start	3,532,778 bp^[2]
Band	9\|9 A1	End	3,894,736 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

visceral pleura

saphenous vein

postcentral gyrus

lower lobe of lung

external globus pallidus

vena cava

endothelial cell

seminal vesicula

entorhinal cortex

Top expressed in

superior frontal gyrus

cerebellar cortex

spermatid

yolk sac

neural tube

esophagus

ganglionic eminence

mirror

spermatocyte

hippocampus proper

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	GTP binding heme binding nucleotide binding phosphorus-oxygen lyase activity lyase activity protein binding guanylate cyclase activity adenylate cyclase activity
Cellular component	plasma membrane guanylate cyclase complex, soluble cytoplasm
Biological process	signal transduction intracellular signal transduction cyclic nucleotide biosynthetic process cGMP biosynthetic process positive regulation of nitric oxide mediated signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2977


234889

Ensembl


ENSG00000152402


ENSMUSG00000041624

UniProt


P33402


n/a

RefSeq (mRNA)


NM_001256424 NM_000855


NM_001033322

RefSeq (protein)


NP_000846 NP_001243353


n/a

Location (UCSC)

Chr 11: 106.67 – 107.02 Mb

Chr 9: 3.53 – 3.89 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152402 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041624 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett. 292 (1–2): 217–22. doi:10.1016/0014-5793(91)80871-Y. PMID 1683630. S2CID 84974514.
^ "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2".

Baba H, Suzuki T, Arai H, Emson PC (2004). "Expression of nNOS and soluble guanylate cyclase in schizophrenic brain". NeuroReport. 15 (4): 677–80. doi:10.1097/00001756-200403220-00020. PMID 15094474. S2CID 45536193.
Bellamy TC, Wood J, Garthwaite J (2002). "On the activation of soluble guanylyl cyclase by nitric oxide". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 507–10. Bibcode:2002PNAS...99..507B. doi:10.1073/pnas.012368499. PMC 117590. PMID 11752394.
Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
Bamberger AM, Koglin M, Kempfert J, et al. (2001). "Expression and tissue localization of soluble guanylyl cyclase in the human placenta using novel antibodies directed against the alpha(2) subunit". J. Clin. Endocrinol. Metab. 86 (2): 909–12. doi:10.1210/jcem.86.2.7409. PMID 11158065.
Budworth J, Meillerais S, Charles I, Powell K (1999). "Tissue distribution of the human soluble guanylate cyclases". Biochem. Biophys. Res. Commun. 263 (3): 696–701. doi:10.1006/bbrc.1999.1444. PMID 10512742.
Yu F, Warburton D, Wellington S, Danziger RS (1997). "Assignment of GUCIA2, the gene coding for the alpha 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11". Genomics. 33 (2): 334–6. doi:10.1006/geno.1996.0208. PMID 8660992.
Behrends S, Harteneck C, Schultz G, Koesling D (1995). "A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein". J. Biol. Chem. 270 (36): 21109–13. doi:10.1074/jbc.270.36.21109. PMID 7673142.

Phosphorus–oxygen lyases (EC 4.6)

4.6.1

Adenylate cyclase
(4.6.1.1)

intracellular	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCY10
extracellular	Extracellular adenylate cyclase

Guanylate cyclase
(4.6.1.2)

soluble guanylyl cyclase	GUCY1A2 GUCY1A3 GUCY1B2 GUCY1B3
guanylate cyclase-coupled receptor	GUCY2C GUCY2D ANP (NPR1 NPR2)

Other

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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This page was last edited on 8 November 2023, at 16:13

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References

Further reading