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| Names | |
|---|---|
| IUPAC name
3-carbamoylamino-2-methoxypropylmercury(II) chloride
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| Systematic IUPAC name
3-chloro-mercura-2-methoxy propylurea | |
Other names
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| Identifiers | |
3D model (JSmol)
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| ECHA InfoCard | 100.000.483 |
PubChem CID
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| Properties | |
| C5H11ClHgN2O2 | |
| Molar mass | 367.20 g·mol−1 |
| Appearance | Solid |
| Melting point | 152.5 °C (306.5 °F; 425.6 K) |
| 11 g/L | |
| Hazards | |
| Occupational safety and health (OHS/OSH): | |
Main hazards
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Renal mercury poisoning |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Clinical data | |
|---|---|
| AHFS/Drugs.com | Medical Encyclopedia |
| ATC code |
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| Legal status | |
| Legal status |
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| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| ChEBI | |
| ChEMBL | |
| ECHA InfoCard | 100.000.483 |
| Chemical and physical data | |
| Formula | C5H11ClHgN2O2 |
| Molar mass | 367.20 g·mol−1 |
| 3D model (JSmol) | |
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Chlormerodrin is a mercurial diuretic commercially traded from 1952[1] until 1974[2] that was once used to treat patients with heart failure,[3] but is no longer in widespread use.[4] The radiolabelled form (197Hg & 203Hg) had also been used for medical imaging of the kidney and brain[5][6] and the 197Hg form was even considered a contender for 99mTc by some physicians,[7] but was ultimately discontinued by the FDA in 1989.[8]
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Transcription
References
- ^ Sittig M (1988). Pharmaceutical Manufacturing Encyclopedia. Westwood: Noyes Publications.
- ^ Crout JR (1974). "Fixed combination prescription drugs: FDA policy". Journal of Clinical Pharmacology. 14 (5–6): 249–254. doi:10.1002/j.1552-4604.1974.tb02309.x. PMID 4829517. S2CID 5830209.
- ^ Leff WA, Nussbaum HE (April 1959). "Chlormerodrin: clinical effectiveness and absence of toxicity in congestive heart failure; report of a four-year study". British Medical Journal. 1 (5126): 883–889. doi:10.1136/bmj.1.5126.883. PMC 1992943. PMID 13629153.
- ^ "Chlormerodrin". PubChem. U.S. National Library of Medicine. Retrieved 2021-09-23.
- ^ Sodee DB, Di Stefano B (September 1965). "The Clinical Value of Today's Radioisotope Scanning". The Ohio State Medical Journal. 61: 819–22. PMID 14340215.
- ^ Yamamoto YL, Feindel W, Zanelli J (September 1964). "Comparative study of radioactive chlormerodrin (Neohydrin) tagged with mercury 197 and mercury 203 for brain scanning". Neurology. 14 (9): 815–820. doi:10.1212/wnl.14.9.815. PMID 14215595. S2CID 43526449.
- ^ Sodee DB (December 1968). "Comparison of 99mTc-pertechnetate and 197Hg-chlormerodrin for brain scanning". Journal of Nuclear Medicine. 9 (12): 645. PMID 5729215.
- ^ FDA, Approved Drug Products with Therapeutic Equivalence Evaluations, US Department Of Health And Human Service, 1989.
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This page was last edited on 25 March 2024, at 07:53