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Ro01-6128

From Wikipedia, the free encyclopedia

Ro01-6128
Identifiers
  • ethyl diphenylacetylcarbamate
PubChem CID
IUPHAR/BPS
ChemSpider
Chemical and physical data
FormulaC17H17NO3
Molar mass283.327 g·mol−1
3D model (JSmol)
  • c2ccccc2C(C(=O)NC(=O)OCC)c1ccccc1
  • InChI=1S/C17H17NO3/c1-2-21-17(20)18-16(19)15(13-9-5-3-6-10-13)14-11-7-4-8-12-14/h3-12,15H,2H2,1H3,(H,18,19,20)
  • Key:ILSZPWZFQHSKLW-UHFFFAOYSA-N
  (verify)

Ro01-6128 is a drug used in scientific research, which acts as a selective positive allosteric modulator for the metabotropic glutamate receptor subtype mGluR1.[1][2][3] It was derived by modification of a lead compound found via high-throughput screening, and was further developed to give the improved compound Ro67-4853.[4]

References

  1. ^ Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA (November 2001). "Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site". Proceedings of the National Academy of Sciences of the United States of America. 98 (23): 13402–7. Bibcode:2001PNAS...9813402K. doi:10.1073/pnas.231358298. PMC 60883. PMID 11606768.
  2. ^ Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ (August 2006). "A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators". Molecular Pharmacology. 70 (2): 616–26. doi:10.1124/mol.105.021857. PMID 16645124. S2CID 2719603.
  3. ^ Sheffler DJ, Conn PJ (September 2008). "Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells". Neuropharmacology. 55 (4): 419–27. doi:10.1016/j.neuropharm.2008.06.047. PMC 2600811. PMID 18625258.
  4. ^ Wichmann J, Bleicher K, Vieira E, Woltering T, Knoflach F, Mutel V (December 2002). "Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors". Farmaco. 57 (12): 989–92. doi:10.1016/s0014-827x(02)01283-1. PMID 12564473.
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This page was last edited on 20 December 2023, at 19:41
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