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RN-9893

From Wikipedia, the free encyclopedia

RN-9893
Identifiers
  • 2-nitro-N-[4-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]-4-(trifluoromethyl)benzamide
CAS Number
PubChem CID
Chemical and physical data
FormulaC21H23F3N4O5S
Molar mass500.49 g·mol−1
3D model (JSmol)
  • CC(C)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=C(C=C(C=C3)C(F)(F)F)[N+](=O)[O-]
  • InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
  • Key:KORKKQLDGMHNKO-UHFFFAOYSA-N

RN-9893 is a drug which acts as a potent and selective blocker of the TRPV4 ion channel. It has been used to investigate the role of TRPV4 channels in the function of heart valves.[1][2]

See also

References

  1. ^ Wei ZL, Nguyen MT, O'Mahony DJ, Acevedo A, Zipfel S, Zhang Q, et al. (September 2015). "Identification of orally-bioavailable antagonists of the TRPV4 ion-channel". Bioorganic & Medicinal Chemistry Letters. 25 (18): 4011–5. doi:10.1016/j.bmcl.2015.06.098. PMID 26235950.
  2. ^ Al-Shammari H, Latif N, Sarathchandra P, McCormack A, Rog-Zielinska EA, Raja S, et al. (2020). "Expression and function of mechanosensitive ion channels in human valve interstitial cells". PLOS ONE. 15 (10): e0240532. Bibcode:2020PLoSO..1540532A. doi:10.1371/journal.pone.0240532. PMC 7561104. PMID 33057457.
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This page was last edited on 26 January 2023, at 11:49
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