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ASP-7663

From Wikipedia, the free encyclopedia

ASP-7663
Names
Preferred IUPAC name
(E)-[7-Fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]acetic acid
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+
    Key: RCVZUIGCNAAMIC-UXBLZVDNSA-N
  • CC(C)CN1C2=C(C=CC=C2F)/C(=C\C(=O)O)/C1=O
Properties
C14H14FNO3
Molar mass 263.268 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

ASP-7663 is a chemical compound which acts as a potent, selective activator of the TRPA1 channel. It has protective effects on cardiac tissue, and is used for research into the function of the TRPA1 receptor.[1][2]

See also

References

  1. ^ Pan Y, Zhao G, Cai Z, Chen F, Xu D, Huang S, et al. (2016). "Synergistic Effect of Ferulic Acid and Z-Ligustilide, Major Components of A. sinensis, on Regulating Cold-Sensing Protein TRPM8 and TPRA1 In Vitro". Evidence-Based Complementary and Alternative Medicine. 2016: 3160247. doi:10.1155/2016/3160247. PMC 4931054. PMID 27413384. S2CID 14007898.
  2. ^ Lu Y, Piplani H, McAllister SL, Hurt CM, Gross ER (December 2016). "Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents". Anesthesiology. 125 (6): 1171–1180. doi:10.1097/ALN.0000000000001377. PMC 5110384. PMID 27748654.
This page was last edited on 24 October 2021, at 21:29
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