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Subunidad M2 B de la ribonucleósido-difosfato reductasa
Estructuras disponibles
PDB

Buscar ortólogos: PDBe, RCSB

 Lista de códigos PDB
 Estructuras enzimáticas
Identificadores
Símbolos RRM2B (HGNC: 17296) DKFZp686M05248; MGC102856; MGC42116; p53R2
Identificadores
externos
Número EC 1.17.4.1
Locus Cr. 8 q22.3
Patrón de expresión de ARNm
ancho=250px
Más información
Ortólogos
Especies
Humano Ratón
Entrez
50484 382985
Ensembl
Véase HS Véase MM
UniProt
Q7LG56  Q6PEE3 
RefSeq
(ARNm)
NM_001172477 NM_199476
RefSeq
(proteína) NCBI
NP_001165948 NP_955770
Ubicación (UCSC)
Cr. 8:
103.22 – 103.25 Mb
Cr. 15:
37.92 – 37.96 Mb
PubMed (Búsqueda)
[1]


[2]

La subunidad M2 B de la ribonucleósido-difosfato reductasa (RRM2B) es una enzima codificada en humanos por el gen RRM2B.[1][2][3][4]

Interacciones

La proteína RRM2B ha demostrado ser capaz de interaccionar con:

Referencias

  1. Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y, Nakamura Y (Apr de 2000). «A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage». Nature 404 (6773): 42-9. PMID 10716435. doi:10.1038/35003506. 
  2. Nakano K, Balint E, Ashcroft M, Vousden KH (Oct de 2000). «A ribonucleotide reductase gene is a transcriptional target of p53 and p73». Oncogene 19 (37): 4283-9. PMID 10980602. 
  3. Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, Chretien D, de Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y, Munnich A, Rotig A (mayo de 2007). «Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion». Nat Genet 39 (6): 776-80. PMID 17486094. doi:10.1038/ng2040. 
  4. «Entrez Gene: RRM2B ribonucleotide reductase M2 B (TP53 inducible)». 
  5. a b Chang, Lufen; Zhou Bingsen, Hu Shuya, Guo Robin, Liu Xiyong, Jones Stephen N, Yen Yun (Nov. de 2008). «ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage». Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (47): 18519-24. PMID 19015526. doi:10.1073/pnas.0803313105. 
Esta página se editó por última vez el 23 oct 2019 a las 08:09.
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