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RRM2

De Wikipedia, la enciclopedia libre

Subunidad M2 de ribonucleósido-difosfato reductasa.
Estructuras disponibles
PDB

Buscar ortólogos:

 Estructuras enzimáticas
RCSB PDB, PDBe, PDBsum
Identificadores
Identificadores
externos
 Bases de datos de enzimas
IntEnz: entrada en IntEnz
BRENDA: entrada en BRENDA
ExPASy: NiceZime view
KEGG: entrada en KEEG
PRIAM: perfil PRIAM
ExplorEnz: entrada en ExplorEnz
MetaCyc: vía metabólica
Número EC 2.3.2.8
Estructura/Función proteica
Funciones Cataliza la formación de desoxirribonucleótidos.
UniProt
P31350  n/a
PubMed (Búsqueda)
[1]


PMC (Búsqueda)
[2]
[editar datos en Wikidata]

La subunidad M2 de ribonucleósido-difosfato reductasa, también conocida como subunidad pequeña de ribonucleótido reductasa, es una enzima que en humanos está codificada por el gen RRM2.[1]​[2]​[3]​

Función

Este gen codifica una de las dos subunidades no idénticas de la ribonucleótido reductasa.[4]​ Esta reductasa cataliza la formación de desoxirribonucleótidos a partir de ribonucleótidos. La síntesis de la proteína codificada (M2) se regula de forma dependiente del ciclo celular.[5]​ La transcripción de este gen puede ser iniciada por promotores alternativos, lo que da como resultado dos isoformas que difieren en las longitudes de sus N-terminales.[1]​

Mapa interactivo

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FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article

Referencias

  1. ↑ a b «Entrez Gene: ribonucleotide reductase M2». 
  2. ↑ «Sequence analysis of the large and small subunits of human ribonucleotide reductase». DNA Seq. 2 (4): 227-34. 1992. PMID 1627826. doi:10.3109/10425179209020807. 
  3. ↑ «Uniprot: RRM2». 
  4. ↑ «RRM2 Gene - GeneCards | RIR2 Protein | RIR2 Antibody». www.genecards.org. Consultado el 24 de septiembre de 2020. 
  5. ↑ «RRM2 (ribonucleotide reductase M2)». atlasgeneticsoncology.org. Consultado el 24 de septiembre de 2020. 
Esta página se editó por última vez el 11 nov 2023 a las 18:45.
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