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RPS6KA4

De Wikipedia, la enciclopedia libre

Proteína cinasa S6 ribosomal alfa 4
Estructuras disponibles
PDB

Buscar ortólogos: PDBe, RCSB

 Estructuras enzimáticas
RCSB PDB, PDBe, PDBsum
Identificadores
Símbolos RPS6KA4 (HGNC: 10433) MSK2, RSK-B
Identificadores
externos
 Bases de datos de enzimas
IntEnz: entrada en IntEnz
BRENDA: entrada en BRENDA
ExPASy: NiceZime view
KEGG: entrada en KEEG
PRIAM: perfil PRIAM
ExplorEnz: entrada en ExplorEnz
MetaCyc: vía metabólica
Número EC 2.7.11.1
Locus Cr. 11 q13.1
Ortólogos
Especies
Humano Ratón
Entrez
8986
UniProt
O75676   n/a
RefSeq
(ARNm)
NP_001006945 n/a
PubMed (Búsqueda)
[1]


PMC (Búsqueda)
[2]
[editar datos en Wikidata]

La proteína cinasa S6 ribosomal alfa 4 (RPS6KA4) es una enzima codificada en humanos por el gen HGNC RPS6KA4 .[1]​[2]​[3]​ Su actividad enzimática se encuentra descripta por el número EC 2.7.11.1.

La proteína RPS6KA4 pertenece a la familia de las serina/treonina proteína cinasas RSK (cinasa S6 ribosomal). Esta cinasa contiene dos dominios catalíticos no idénticos y fosforila varios sustratos, incluyendo CREB1 y c-Fos. Se han descrito variantes transcripcionales del gen pero no todas ellas han sido caracterizadas.[3]​

Interacciones

La proteína RPS6KA4 ha demostrado ser capaz de interaccionar con:

Referencias

  1. ↑ a b Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec de 1998). «RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)». J Biol Chem (EE. UU.) 273 (45): 29661-71. ISSN 0021-9258. PMID 9792677. 
  2. ↑ Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep de 1998). «Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB». EMBO J 17 (15): 4426-41. PMC 1170775. PMID 9687510. doi:10.1093/emboj/17.15.4426. 
  3. ↑ a b «Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4». 

[[Categoría:Serina/treonina proteína c inasas]]

Esta página se editó por última vez el 2 dic 2021 a las 23:01.
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