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Glucocinasa

De Wikipedia, la enciclopedia libre

Glucocinasa
Identificadores
[editar datos en Wikidata]
Glucocinasa humana + D-glucosa (verde) + Na (azul claro)

La glucocinasa o glucoquinasa es una isoenzima tipo IV que se encuentra exclusivamente en el hígado y en células beta de los islotes de Langerhans en el páncreas. Es altamente específica, por lo que solo utiliza D-glucosa como sustrato y su afinidad por otras hexosas es mucho menor que de las otras isoenzimas (KM mayor de 10 mM).

La actividad de esta enzima depende de la glucosa disponible; es pobre a valores de glucemia normal en ayunas. A diferencia de las hexocinasas I II III no se inhibe por la glucosa-6-P producto de la fosforilación de glucosa catalizada por glucocinasa (hígado y páncreas) o hexocinasa.

Esta página se editó por última vez el 3 dic 2021 a las 18:52.
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