ZBED6

ZBED6

Identifiers

ZBED6, MGR, zinc finger BED-type containing 6

External IDs

OMIM: 613512 MGI: 3828086 HomoloGene: 130066 GeneCards: ZBED6

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q32.1	Start	203,795,714 bp^[1]
Band	1q32.1	End	203,854,999 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 E4	Start	133,547,678 bp^[2]
Band	1\|1 E4	End	133,589,056 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bone marrow cells

thymus

islet of Langerhans

stromal cell of endometrium

Achilles tendon

duodenum

smooth muscle tissue

sural nerve

gallbladder

gastrocnemius muscle

Top expressed in

ascending aorta

aortic valve

olfactory tubercle

arcuate nucleus

median eminence

medial geniculate nucleus

inferior colliculus

paraventricular nucleus of hypothalamus

medial dorsal nucleus

globus pallidus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	DNA binding protein dimerization activity metal ion binding DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	nucleolus nucleus
Biological process	negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


100381270


667118

Ensembl


ENSG00000257315


ENSMUSG00000094410

UniProt


P86452


D2EAC2

RefSeq (mRNA)


NM_001174108 NM_001395895


NM_001166552 NM_001395904

RefSeq (protein)


NP_001167579


NP_001160024 NP_001382833

Location (UCSC)

Chr 1: 203.8 – 203.85 Mb

Chr 1: 133.55 – 133.59 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Zinc finger, BED-type containing 6 is a protein that in humans is encoded by the ZBED6 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000257315 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000094410 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Zinc finger, BED-type containing 6". Retrieved 2012-03-15.

Markljung E, Jiang L, Jaffe JD, Mikkelsen TS, Wallerman O, Larhammar M, Zhang X, Wang L, Saenz-Vash V, Gnirke A, Lindroth AM, Barrés R, Yan J, Strömberg S, De S, Pontén F, Lander ES, Carr SA, Zierath JR, Kullander K, Wadelius C, Lindblad-Toh K, Andersson G, Hjälm G, Andersson L (Dec 2009). O'Rahilly S (ed.). "ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth". PLOS Biology. 7 (12): e1000256. doi:10.1371/journal.pbio.1000256. PMC 2780926. PMID 20016685.
Butter F, Kappei D, Buchholz F, Vermeulen M, Mann M (Apr 2010). "A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth". EMBO Reports. 11 (4): 305–11. doi:10.1038/embor.2010.6. PMC 2854606. PMID 20134481.
Andersson L (2010). "Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin". Cold Spring Harbor Symposia on Quantitative Biology. 74: 319–25. doi:10.1101/sqb.2009.74.039. PMID 20375320.

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This page was last edited on 28 November 2023, at 01:43

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References

Further reading