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What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
A single oral dose of 8.3 mg/kg ZB716 to mice has been found to result in an over 160 ng/mL (160,000 pg/mL) maximal concentration of the drug in circulation, a level far in excess of the 15.2 ng/mL (15,200 pg/mL) concentration achieved with subcutaneous injection of fulvestrant in mice.[1] As such, not only may ZB716 be more convenient to administer in humans, it has far greater bioavailability compared to fulvestrant and hence may allow for greater systemic exposure and therapeutic benefit.[1]
ZB716 produces fulvestrant as an active metabolitein vivo in mice, with approximately 10 to 15% of the drug being converted into it.[1] As such, most of the effects are likely due to the parent drug.[1]
Clinical Development
As of December 2020, it is in a phase I clinical trial for ER+/HER2- metastatic breast cancer.[2]