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Young's syndrome

From Wikipedia, the free encyclopedia

Young's syndrome
Other namesAzoospermia sinopulmonary infections
Autosomal recessive - en.svg
Young's syndrome is inherited in an autosomal recessive manner

Young's syndrome, also known as azoospermia sinopulmonary infections, sinusitis-infertility syndrome and Barry-Perkins-Young syndrome, is a rare condition that encompasses a combination of syndromes such as bronchiectasis, rhinosinusitis and reduced male fertility.[1][2][3] In individuals with this syndrome the functioning of the lungs is usually normal but the mucus is abnormally viscous. The reduced fertility (obstructive azoospermia) is due to functional obstruction of sperm transport down the genital tract at the epididymis, where the sperm is found in viscous, lipid-rich fluid.[3][4] The syndrome was named after Donald Young,[5] the urologist who first made observations of the clinical signs of the syndrome in 1972.[6]

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See also


  1. ^ Handelsman DJ, Conway AJ, Boylan LM, Turtle JR (January 1984). "Young's syndrome. Obstructive azoospermia and chronic sinopulmonary infections". N. Engl. J. Med. 310 (1): 3–9. doi:10.1056/NEJM198401053100102. PMID 6689737.
  2. ^ Young syndrome at NIH's Office of Rare Diseases
  3. ^ a b Young's syndrome - General Practice Notebook
  4. ^ Definition: Young syndrome from Online Medical Dictionary
  5. ^ Young, M (January 2003). "Obituary of Donald Herron Young". BMJ. 326 (7382): 226. doi:10.1136/bmj.326.7382.226/g. PMC 1125087.
  6. ^ Online Mendelian Inheritance in Man (OMIM): Young syndrome - 279000

External links

This page was last edited on 20 November 2020, at 20:05
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