To install click the Add extension button. That's it.

The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.

4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Live Statistics
English Articles
Improved in 24 Hours
Added in 24 Hours
Languages
Recent
Show all languages
What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
.
Leo
Newton
Brights
Milds

Juvenile xanthogranuloma

From Wikipedia, the free encyclopedia

Juvenile xanthogranuloma
Other namesJXG
Yellow papule on the right inner arm of a toddler
SpecialtyHematology Edit this on Wikidata

Juvenile xanthogranuloma is a form of histiocytosis, classified as non-Langerhans cell histiocytosis.[1][2] It is a rare skin disorder that primarily affects children under one year of age but can also be found in older children and adults.[3]

It was first described in 1905 by Adamson.[4] In 5% to 17% of people, the disorder is present at birth, but the median age of onset is two years. JXG is a benign idiopathic cutaneous granulomatous tumor and the most common form of non-Langerhans cell histiocytosis (non-LHC).[3] The lesions appear as orange-red macules or papules and are usually located on the face, neck, and upper trunk. They may also appear at the groin, scrotum, penis, clitoris, toenail, palms, soles, lips, lungs, bone, heart, and gastrointestinal tract more rarely.[4] JXG usually manifests with multiple lesions on the head and neck in cases with children under six months of age. The condition usually resolves spontaneously over one to five years.[3] A biopsy of the lesion is critical to confirm the diagnosis.[5]

Histopathology of juvenile xanthogranuloma characteristiclaly shows scattered Touton giant cells.[6]

Ocular JXG manifests in up to 10% of people with JXG and may affect their vision.[3] The presence of JXG in the eye can cause spontaneous hyphema, secondary glaucoma or even blindness.[3][5] It is most often seen in the iris but may be found on the eyelid, corneoscleral limbus, conjunctiva, orbit, retina, choroid, optic disc, or optic nerve. Of patients with ocular JXG, 92% are younger than the age of two.[4] Although cutaneous JXG usually disappear spontaneously, ocular lesions rarely improve spontaneously and require treatment. Treatments that have been used include surgical excision, intralesional steroid injection, cryotherapy, and low dose radiotherapy. In the case of a resistant or reoccurring lesion, chemotherapy has been used as a treatment. Ocular JXG is usually unilateral and presents with a tumor, a red eye with signs of uveitis, unilateral glaucoma, spontaneous hyphema or heterochromia iridis. Diagnosing and treating the patient as early as possible contributes to the most positive visual outcome.

Histiocytic disorders like JXG are identified by the cells that make them up.[4] Immunohistochemical analysis is used to discern the immunoreactivity to certain antibodies in these analyses. JXG is a non-LHC disorder which is a varied group of disorders defined by the accumulation of histiocytes that do not meet criteria to be diagnosed as Langerhans cells. JXG is not metastatic and may be present with lipid deposits. JXG is often accompanied with other disorders such as neurofibromatosis type I and juvenile chronic myelogenous leukemia. Juvenile variety xanthogranuloma can be distinguished from xanthoma by the spread of the lesion and the lack of lipid abnormalities. Other similar diagnoses include molluscum contagiosum, hemangioma and neurofibroma.[4]

YouTube Encyclopedic

  • 1/3
    Views:
    653
    4 560
    401
  • Juvenile xanthogranuloma WITHOUT Touton giant cells JXG pathology dermpath dermatology
  • Juvenile Xanthogranuloma (JXG): 5-Minute Pathology Pearls for Dermatopathology & Dermatology
  • Dermoscopy of juvenile xanthogranuloma in children | Dr Vincenzo Piccolo

Transcription

See also

References

  1. ^ Nakasu S, Tsuji A, Fuse I, Hirai H (2007). "Intracranial solitary juvenile xanthogranuloma successfully treated with stereotactic radiosurgery". J. Neurooncol. 84 (1): 99–102. doi:10.1007/s11060-007-9351-1. PMID 17332947. S2CID 31446690.
  2. ^ DermNet lesions/xanthogranuloma
  3. ^ a b c d e Kim MS, Kim SA, Sa HS (March 2014). "Old-age-onset subconjunctival juvenile xanthogranuloma without limbal involvement". BMC Ophthalmol. 14: 24. doi:10.1186/1471-2415-14-24. PMC 3946074. PMID 24602225.
  4. ^ a b c d e Cypel TK, Zuker RM (2008). "Juvenile xanthogranuloma: case report and review of the literature". Can J Plast Surg. 16 (3): 175–7. doi:10.1177/229255030801600309. PMC 2691016. PMID 19721800.
  5. ^ a b Lau HH, Yip WW, Lee A, Lai C, Fan DS (June 2014). "Three different ophthalmic presentations of juvenile xanthogranuloma". Hong Kong Med J. 20 (3): 261–3. doi:10.12809/hkmj134059. PMID 24914080.
  6. ^ Hamie, Lamiaa; Abbas, Ossama (24 May 2021). "Juvenile xanthogranuloma". Skin nonmelanocytic tumor: Other tumors of skin. Pathology Outlines.

External links

This page was last edited on 13 June 2024, at 08:45
Basis of this page is in Wikipedia. Text is available under the CC BY-SA 3.0 Unported License. Non-text media are available under their specified licenses. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. WIKI 2 is an independent company and has no affiliation with Wikimedia Foundation.