| Clinical data | |
|---|---|
| Trade names | Vpriv |
| AHFS/Drugs.com | Monograph |
| License data |
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| Routes of administration | Intravenous |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | N/A |
| Elimination half-life | Plasma: 5–12 minutes (absorbed by macrophages) |
| Identifiers | |
| CAS Number | |
| DrugBank | |
| ChemSpider |
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| UNII | |
| KEGG | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C2532H3850N672O711S16 |
| Molar mass | 55593.61 g·mol−1 |
  (what is this?) (verify) | |
Velaglucerase alfa, sold under the brand name Vpriv, is a medication used for the treatment of Gaucher disease Type 1.[1] It is a hydrolytic lysosomal glucocerebroside-specific enzyme, which is a recombinant form of glucocerebrosidase. It has an identical amino acid sequence to the naturally occurring enzyme.[2] It is manufactured by Shire plc.
The most common side effects include abdominal (belly) pain, headache, dizziness, bone pain, arthralgia (joint pain), back pain, infusion-related reactions, asthenia (weakness) or fatigue (tiredness), and pyrexia (fever) or increased body temperature.[3]
Velaglucerase alfa was approved for medical use in the United States in February 2010,[4][5] and in the European Union in August 2010.[3]
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Spot the Early Signs of Gaucher Disease
Transcription
Medical uses
Velaglucerase alfa is indicated for long-term enzyme-replacement therapy (ERT) in people with type-1 Gaucher disease.[3][1]
References
- ^ a b c "Vpriv- velaglucerase alfa injection, powder, lyophilized, for solution". DailyMed. 18 June 2020. Archived from the original on 24 March 2021. Retrieved 13 August 2020.
- ^ Burrow TA, Grabowski GA (February 2011). "Velaglucerase alfa in the treatment of Gaucher disease type 1". Clinical Investigation. 1 (2): 285–293. doi:10.4155/cli.10.21. PMC 3172711. PMID 21927713.
- ^ a b c "Vpriv EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 29 October 2020. Retrieved 13 August 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ "Shire Announces FDA Approval Of Vpriv (velaglucerase Alfa For Injection) For The Treatment Of Type 1 Gaucher Disease". Medical News Today. 27 February 2010. Archived from the original on 13 June 2011. Retrieved 6 March 2010.
- ^ "Drug Approval Package: Vpriv (Velaglucerase alfa) NDA #022575". U.S. Food and Drug Administration (FDA). 24 February 2010. Archived from the original on 3 April 2021. Retrieved 17 February 2023.
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This page was last edited on 14 March 2024, at 07:13