 | |
| Company type | Public |
|---|---|
| |
| Industry | Biotechnology, Pharmaceutical |
| Predecessor | Forge, Inc. |
| Founded | 2011 in California, United States of America |
| Founders |
|
| Headquarters | , |
Number of employees | 70 (2018) |
| Website | unitybiotechnology |
Unity Biotechnology is a publicly traded American biotechnology company that develops drugs that target senescent cells.[1][2][3][4][5]
History
Unity BioTechnologies, a company backed by Jeff Bezos and PayPal co-founder Peter Thiel,[6] was co-founded in March 2009 by Nathaniel David, Jan Van Deursen, Judith Campisi, and Daohong Zhou.[7]
The company was founded under the name Forge, Inc., but changed its name to Unity BioTechnologies in January 2015.[8]
Anirvan Ghosh joined Unity in 2020 as the company’s CEO. That same year, Nathaniel stepped down as president but remained a member of the board.[9]
On May 3, 2018, the company went public on the Nasdaq exchange, raising $85 million at a market capitalization of $700 million.[10][11] Unity Biotechnology shares dropped 60% on August 17, 2020, after the company reported disappointing results from a clinical trial involving its then lead drug candidate, UBX0101, in patients with moderate-to-severe painful osteoarthritis.[12]
Products
The company's products in development include UBX1325, which targets Bcl-xL, a mechanism to eliminate senescent cells in age-related eye diseases (in Phase 2 clinical trials for diabetic macular edema as of October 2023).[13] In July 2022, the company reported positive results from its Phase 1 study.[14] In April 2023, the company then reported results from its Phase 2 study demonstrating that a single injection of UBX1325 resulted in a statistically significant and clinically meaningful improvement in vision through 48 weeks.[15] They also include UBX 1967, a preclinical product targeting ophthalmologic diseases.[16][11][17] Both products are senolytic medicines.
See also
References
- ^ Brueck, Hilary (3 February 2016). "Mayo Clinic Taps Silicon Valley to Help People Age Gracefully". Fortune. Retrieved 19 February 2018.
- ^ Detrixhe, John (21 February 2018). "Crypto millionaires are funding research to reverse the aging process". Quartz (publication). Retrieved 19 February 2018.
- ^ Herkewitz, William (19 February 2018). "Scientists Can Now Radically Expand the Lifespan of Mice—and Humans May Be Next". Popular Mechanics. Retrieved 19 February 2018.
- ^ Ramsey, Lydia (10 November 2016). "A biotech startup that aims to rid our bodies of cells related to aging just got a big investment". Business Insider. Retrieved 19 February 2018.
- ^ Baker, Darren (11 February 2016). "Naturally occurring p16Ink4a-positive cells shorten healthy lifespan". Nature. 530 (7589): 184–189. doi:10.1038/nature16932. PMC 4845101. PMID 26840489.
- ^ Zaleski, Andrew (2018-08-29). "Why Jeff Bezos is backing this Silicon Valley scientist who is working on a cure for aging". CNBC. Retrieved 2024-01-03.
- ^ "UBX | Unity Biotechnology Inc. Company Profile & Executives - WSJ". www.wsj.com. Retrieved 2024-01-03.
- ^ "S-1". www.sec.gov. Retrieved 2024-01-04.
- ^ Leuty, Ron (15 December 2020). "Founder steps down from president job at aging-fighting biotech". www.bizjournals.com. Retrieved 2024-01-11.
- ^ CNBC (2018-05-02). "UNITY Biotechnology, Inc. Announces Pricing of Initial Public Offering of Common Stock". CNBC. Retrieved 2018-10-12.
- ^ a b "Longevity Company Unity Biotechnology Stocks Soared After CEO Talks to CNBC | BioSpace". BioSpace. Retrieved 2018-10-12.
- ^ "Buzzy anti-aging biotech Unity drops leading program after flop, shares in freefall". 2020-08-17.
- ^ "Design for Phase 2B ASPIRE Study of UBX1325 for DME announced by UNITY". Modern Retina. 2023-06-22. Retrieved 2023-10-17.
- ^ Bankhead, Charles (2022-07-14). "'Senolytic' Therapy Shows Promise in Neovascular Eye Disease". www.medpagetoday.com. Retrieved 2022-07-15.
- ^ Garth, Eleanor (2023-05-10). "Getting comfortable with senotherapeutics". Longevity.Technology - Latest News, Opinions, Analysis and Research. Retrieved 2023-10-17.
- ^ "S-1". www.sec.gov. Retrieved 2018-10-12.
- ^ "Unity Biotechnology to focus on senolytic programs in ophthalmology, neurology". www.healio.com. Retrieved 2020-12-08.
External links
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This page was last edited on 11 January 2024, at 19:01