UNC5A

UNC5A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4V2A

Identifiers

Aliases

UNC5A, UNC5H1, unc-5 netrin receptor A

External IDs

OMIM: 607869; MGI: 894682; HomoloGene: 41474; GeneCards: UNC5A; OMA:UNC5A - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q35.2	Start	176,810,519 bp^[1]
Band	5q35.2	End	176,880,898 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 B1	Start	55,097,224 bp^[2]
Band	13\|13 B1	End	55,153,831 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

middle temporal gyrus

Brodmann area 23

prefrontal cortex

superior frontal gyrus

Brodmann area 9

postcentral gyrus

cingulate gyrus

ganglionic eminence

entorhinal cortex

Top expressed in

secondary oocyte

superior frontal gyrus

hippocampus proper

humerus

Anterior olfactory nucleus

cerebellar cortex

Meckel's cartilage

lateral part of occipital bone

lesser wing of sphenoid bone

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	netrin receptor activity
Cellular component	intrinsic component of plasma membrane integral component of membrane neuronal cell body membrane membrane raft plasma membrane cell projection neuron projection membrane membrane
Biological process	multicellular organism development neuron projection development signal transduction anterior/posterior axon guidance axon guidance apoptotic process netrin-activated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


90249


107448

Ensembl


ENSG00000113763


ENSMUSG00000025876

UniProt


Q6ZN44


Q8K1S4

RefSeq (mRNA)


NM_133369


NM_153131 NM_001311128

RefSeq (protein)


NP_588610


NP_001298057 NP_694771

Location (UCSC)

Chr 5: 176.81 – 176.88 Mb

Chr 13: 55.1 – 55.15 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.^[5]

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM]^[5]

Interactions

UNC5A has been shown to interact with MAGED1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113763 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025876 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".
^ Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.

Arakawa H (December 2004). "Netrin-1 and its receptors in tumorigenesis". Nature Reviews. Cancer. 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119. S2CID 867903.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (March 2003). "p53RDL1 regulates p53-dependent apoptosis". Nature Cell Biology. 5 (3): 216–23. doi:10.1038/ncb943. PMID 12598906. S2CID 7017409.
Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, et al. (April 2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proceedings of the National Academy of Sciences of the United States of America. 100 (7): 4173–8. Bibcode:2003PNAS..100.4173T. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ (August 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". The Journal of Biological Chemistry. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, et al. (March 2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". The EMBO Journal. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.

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This page was last edited on 18 August 2023, at 22:18

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Interactions

References

Further reading