UHRF2

UHRF2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WY8, 1Z6U, 2E6S, 3OLN, 4PW5, 4PW6, 4PW7, 4TVR

Identifiers

Aliases

UHRF2, NIRF, RNF107, URF2, TDRD23, ubiquitin like with PHD and ring finger domains 2

External IDs

OMIM: 615211 MGI: 1923718 HomoloGene: 17001 GeneCards: UHRF2

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p24.1	Start	6,413,151 bp^[1]
Band	9p24.1	End	6,507,054 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 C1	Start	30,007,913 bp^[2]
Band	19\|19 C1	End	30,071,122 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

pancreatic epithelial cell

Achilles tendon

tibia

thymus

sperm

germinal epithelium

bone marrow

bone marrow cells

superficial temporal artery

Top expressed in

superior cervical ganglion

hand

primitive streak

lens

thymus

otolith organ

utricle

ganglionic eminence

dermis

ureter

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	DNA binding histone binding protein binding metal ion binding ubiquitin protein ligase activity ubiquitin-protein transferase activity transferase activity SUMO transferase activity
Cellular component	nucleus nucleoplasm
Biological process	protein autoubiquitination regulation of DNA methylation-dependent heterochromatin assembly cell cycle cell differentiation cell population proliferation maintenance of DNA methylation protein ubiquitination regulation of cell cycle protein sumoylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


115426


109113

Ensembl


ENSG00000147854


ENSMUSG00000024817

UniProt


Q96PU4


Q7TMI3

RefSeq (mRNA)


NM_152896 NM_152306


NM_144873

RefSeq (protein)


NP_690856


NP_659122

Location (UCSC)

Chr 9: 6.41 – 6.51 Mb

Chr 19: 30.01 – 30.07 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.^[5]^[6]

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147854 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024817 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun. 296 (3): 530–6. doi:10.1016/S0006-291X(02)00890-2. PMID 12176013.
^ ^a ^b "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain". Oncogene. 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834. S2CID 21948278.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Li Y, Mori T, Hata H, et al. (2004). "NIRF induces G1 arrest and associates with Cdk2". Biochem. Biophys. Res. Commun. 319 (2): 464–8. doi:10.1016/j.bbrc.2004.04.190. PMID 15178429.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Mori T, Li Y, Hata H, Kochi H (2004). "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein". FEBS Lett. 557 (1–3): 209–14. doi:10.1016/S0014-5793(03)01495-9. PMID 14741369. S2CID 10006213.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

v t e PDB gallery
1wy8: Solution Structure of the N-terminal Ubiquitin-like Domain in Human Np95/ICBP90-like Ring Finger Protein (NIRF) 1z6u: Np95-like ring finger protein isoform b [Homo sapiens]

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This page was last edited on 14 January 2024, at 13:07

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References

Further reading