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Trequinsin

From Wikipedia, the free encyclopedia

Trequinsin
Names
Preferred IUPAC name
9,10-Dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3
    Key: MCMSJVMUSBZUCN-UHFFFAOYSA-N
  • CC1=CC(=C(C(=C1)C)N=C2C=C3C4=CC(=C(C=C4CCN3C(=O)N2C)OC)OC)C
Properties
C24H27N3O3
Molar mass 405.498 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Trequinsin is a phosphodiesterase inhibitor.[1] It has been shown to improve sperm motility in vitro.[2]

References

  1. ^ Whitaker, RM; Wills, LP; Stallons, LJ; Schnellmann, RG (2013). "CGMP-Selective Phosphodiesterase Inhibitors Stimulate Mitochondrial Biogenesis and Promote Recovery from Acute Kidney Injury". The Journal of Pharmacology and Experimental Therapeutics. 347 (3): 626–34. doi:10.1124/jpet.113.208017. PMC 3836317. PMID 24042162.
  2. ^ McBrinn RC, Fraser J, Hope AG, Gray DW, Barratt CLR, Martins da Silva SJ, Brown SG. Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function. Br J Pharmacol. 2019 Dec;176(23):4521-4536. doi:10.1111/bph.14814 PMID 31368510



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This page was last edited on 6 February 2023, at 15:53
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