Linear trend estimation is a statistical technique to aid interpretation of data. When a series of measurements of a process are treated as a time series, trend estimation can be used to make and justify statements about tendencies in the data, by relating the measurements to the times at which they occurred. This model can then be used to describe the behaviour of the observed data, without explaining it. Linear trend estimation expresses data as a linear function of time, and can also be used to determine the significance of differences in a set of data linked by a categorical factor. An example of the latter from biomedical science would be levels of a molecule in the blood or tissues of patients with incrementally worsening disease  such as mild, moderate and severe.^{[1]}. This is in contrast to an ANOVA, which is reserved for three or more independent groups (e.g. heart disease, cancer, arthritis) (see below).
In particular, it may be useful to determine if measurements exhibit an increasing or decreasing trend which is statistically distinguished from random behaviour. Some examples are determining the trend of the daily average temperatures at a given location from winter to summer, and determining the trend in a global temperature series over the last 100 years. In the latter case, issues of homogeneity are important (for example, about whether the series is equally reliable throughout its length).
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Contents
Fitting a trend: leastsquares
Given a set of data and the desire to produce some kind of model of those data, there are a variety of functions that can be chosen for the fit. If there is no prior understanding of the data, then the simplest function to fit is a straight line with the data values on the y axis, and time (t = 1, 2, 3, ...) on the x axis.
Once it has been decided to fit a straight line, there are various ways to do so, but the most usual choice is a leastsquares fit. This method minimizes the sum of the squared errors in the data series y.
Given a set of points in time , and data values observed for those points in time, values of and are chosen so that
is minimized. Here at + b is the trend line, so the sum of squared deviations from the trend line is what is being minimized. This can always be done in closed form since this is a case of simple linear regression.
For the rest of this article, “trend” will mean the slope of the least squares line, since this is a common convention.
Trends in random data
Before considering trends in real data, it is useful to understand trends in random data.
If a series which is known to be random is analysed – fair dice falls, or computergenerated pseudorandom numbers – and a trend line is fitted through the data, the chances of an exactly zero estimated trend are negligible. But the trend would be expected to be small. If an individual series of observations is generated from simulations that employ a given variance of noise that equals the observed variance of our data series of interest, and a given length (say, 100 points), a large number of such simulated series (say, 100,000 series) can be generated. These 100,000 series can then be analysed individually to calculate estimated trends in each series, and these results establish a distribution of estimated trends that are to be expected from such random data – see diagram. Such a distribution will be normal according to the central limit theorem except in pathological cases. A level of statistical certainty, S, may now be selected – 95% confidence is typical; 99% would be stricter, 90% looser – and the following question can be asked: what is the borderline trend value V that would result in S% of trends being between −V and +V?
The above procedure can be replaced by a permutation test. For this, the set of 100,000 generated series would be replaced by 100,000 series constructed by randomly shuffling the observed data series; clearly such a constructed series would be trendfree, so as with the approach of using simulated data these series can be used to generate borderline trend values V and −V.
In the above discussion the distribution of trends was calculated by simulation, from a large number of trials. In simple cases (normally distributed random noise being a classic) the distribution of trends can be calculated exactly without simulation.
The range (−V, V) can be employed in deciding whether a trend estimated from the actual data is unlikely to have come from a data series that truly has a zero trend. If the estimated value of the regression parameter a lies outside this range, such a result could have occurred in the presence of a true zero trend only, for example, one time out of twenty if the confidence value S=95% was used; in this case, it can be said that, at degree of certainty S, we reject the null hypothesis that the true underlying trend is zero.
However, note that whatever value of S we choose, then a given fraction, 1 − S, of truly random series will be declared (falsely, by construction) to have a significant trend. Conversely, a certain fraction of series that in fact have a nonzero trend will not be declared to have a trend.
Data as trend plus noise
To analyse a (time) series of data, we assume that it may be represented as trend plus noise:
where and are unknown constants and the 's are randomly distributed errors. If one can reject the null hypothesis that the errors are nonstationary, then the nonstationary series {y_{t} } is called trend stationary. The least squares method assumes the errors to be independently distributed with a normal distribution. If this is not the case, hypothesis tests about the unknown parameters a and b may be inaccurate. It is simplest if the 's all have the same distribution, but if not (if some have higher variance, meaning that those data points are effectively less certain) then this can be taken into account during the least squares fitting, by weighting each point by the inverse of the variance of that point.
In most cases, where only a single time series exists to be analysed, the variance of the 's is estimated by fitting a trend to obtain the estimated parameter values and thus allowing the predicted values
to be subtracted from the data (thus detrending the data) and leaving the residuals as the detrended data, and estimating the variance of the 's from the residuals — this is often the only way of estimating the variance of the 's.
Once we know the "noise" of the series, we can then assess the significance of the trend by making the null hypothesis that the trend, , is not different from 0. From the above discussion of trends in random data with known variance, we know the distribution of calculated trends to be expected from random (trendless) data. If the estimated trend, , is larger than the critical value for a certain significance level, then the estimated trend is deemed significantly different from zero at that significance level, and the null hypothesis of zero underlying trend is rejected.
The use of a linear trend line has been the subject of criticism, leading to a search for alternative approaches to avoid its use in model estimation. One of the alternative approaches involves unit root tests and the cointegration technique in econometric studies.
The estimated coefficient associated with a linear time trend variable is interpreted as a measure of the impact of a number of unknown or known but unmeasurable factors on the dependent variable over one unit of time. Strictly speaking, that interpretation is applicable for the estimation time frame only. Outside that time frame, one does not know how those unmeasurable factors behave both qualitatively and quantitatively. Furthermore, the linearity of the time trend poses many questions:
(i) Why should it be linear?
(ii) If the trend is nonlinear then under what conditions does its inclusion influence the magnitude as well as the statistical significance of the estimates of other parameters in the model?
(iii) The inclusion of a linear time trend in a model precludes by assumption the presence of fluctuations in the tendencies of the dependent variable over time; is this necessarily valid in a particular context?
(iv) And, does a spurious relationship exist in the model because an underlying causative variable is itself timetrending?
Research results of mathematicians, statisticians, econometricians, and economists have been published in response to those questions. For example, detailed notes on the meaning of linear time trends in regression model are given in Cameron (2005);^{[2]} Granger, Engle and many other econometricians have written on stationarity, unit root testing, cointegration and related issues (a summary of some of the works in this area can be found in an information paper^{[3]} by the Royal Swedish Academy of Sciences (2003); and HoTrieu & Tucker (1990) have written on logarithmic time trends^{[4]} with results indicating linear time trends are special cases of cycles^{[4]}
Example: noisy time series
It is harder to see a trend in a noisy time series. For example, if the true series is 0, 1, 2, 3 all plus some independent normally distributed "noise" e of standard deviation E, and we have a sample series of length 50, then if E = 0.1 the trend will be obvious; if E = 100 the trend will probably be visible; but if E = 10000 the trend will be buried in the noise.
If we consider a concrete example, the global surface temperature record of the past 140 years as presented by the IPCC:^{[5]} then the interannual variation is about 0.2 °C and the trend about 0.6 °C over 140 years, with 95% confidence limits of 0.2 °C (by coincidence, about the same value as the interannual variation). Hence the trend is statistically different from 0. However, as noted elsewhere this time series doesn't conform to the assumptions necessary for least squares to be valid.
Goodness of fit (rsquared) and trend
The leastsquares fitting process produces a value – rsquared (r^{2}) – which is 1 minus the ratio of the variance of the residuals to the variance of the dependent variable. It says what fraction of the variance of the data is explained by the fitted trend line. It does not relate to the statistical significance of the trend line (see graph); statistical significance of the trend is determined by its tstatistic. Often, filtering a series increases r^{2} while making little difference to the fitted trend.
Real data may need more complicated models
Thus far the data have been assumed to consist of the trend plus noise, with the noise at each data point being independent and identically distributed random variables and to have a normal distribution. Real data (for example climate data) may not fulfill these criteria. This is important, as it makes an enormous difference to the ease with which the statistics can be analysed so as to extract maximum information from the data series. If there are other nonlinear effects that have a correlation to the independent variable (such as cyclic influences), the use of leastsquares estimation of the trend is not valid. Also where the variations are significantly larger than the resulting straight line trend, the choice of start and end points can significantly change the result. That is, the model is mathematically misspecified. Statistical inferences (tests for the presence of trend, confidence intervals for the trend, etc.) are invalid unless departures from the standard assumptions are properly accounted for, for example as follows:
 Dependence: autocorrelated time series might be modeled using autoregressive moving average models.
 Nonconstant variance: in the simplest cases weighted least squares might be used.
 Nonnormal distribution for errors: in the simplest cases a generalised linear model might be applicable.
 Unit root: taking first (or occasionally second) differences of the data, with the level of differencing being identified through various unit root tests.^{[6]}
In R, the linear trend in data can be estimated by using the 'tslm' function of the 'forecast' package.
Trends in clinical data
Medical and biomedical studies often seek to determine a link in sets of data, such as (as indicated above) three different diseases. But data may also be linked in time (such as change in the effect of a drug from baseline, to month 1, to month 2), or by an external factor that may or may not be determined by the researcher and/or their subject (such as no pain, mild pain, moderate pain, severe pain). In these cases one would expect the effect test statistic (e.g. influence of a statin on levels of cholesterol, or the degree of pain) to change in direct order as the effect develops. Suppose the mean level of cholesterol falls from 5.6 mmol/L at baseline to 3.4 mmol/L at one month and to 3.7 mmol/L at two months. Given sufficient power, an ANOVA would most likely find a significant fall at one and two months, but the fall is not linear. Furthermore, a posthoc test may be required. An alternative test may be repeated measures (two way) ANOVA, or Friedeman's test, depending on the nature of the data. Should the cholesterol fall from 5.4 to 4.1 to 3.7, there is a clear linear trend.
A linear trend estimation is a variant of the standard ANOVA, giving different information, and would be the most appropriate test if the researchers are hypothesising a trend effect in their test statistic. The example given by Altman is of levels of serum trypsin in six groups of subjects ordered by age decade (1019 years up to 6069 years). Levels of trypsin (ng/mL) rise in a linear trend of 128, 152, 194, 207, 215, 218. Unsurprisingly, a 'standard' ANOVA gives p<0.0001, whereas linear trend estimation give p=0.00006. Incidentally, it could be reasonably argued that as age is a natural continuously variable index, it should not be categorised into decades, and an effect of age and serum trypsin sought by correlation (assuming the raw data is available).
See also
Notes
 ^ Altman, Douglas (1991). Practical Statistics for Medical Research. London: Chapman and Hall. p. 212220. ISBN 0412276305.
 ^ "Making Regression More Useful II: Dummies and Trends" (PDF). Retrieved June 17, 2012.
 ^ "The Royal Swedish Academy of Sciences" (PDF). 8 October 2003. Retrieved June 17, 2012.
 ^ ^{a} ^{b} "Note on the use of a Logarithm Time Trend" (PDF). Retrieved June 17, 2012.
 ^ "IPCC Third Assessment Report  Climate Change 2001  Complete online versions". Archived from the original on November 20, 2009. Retrieved June 17, 2012.
 ^ Forecasting: principles and practice. 20 September 2014. Retrieved May 17, 2015.
References
 Bianchi, M.; Boyle, M.; Hollingsworth, D. (1999). "A comparison of methods for trend estimation". Applied Economics Letters. 6 (2): 103–109. doi:10.1080/135048599353726.
 Cameron, S. (2005). "Making Regression Analysis More Useful, II". Econometrics. Maidenhead: McGraw Hill Higher Education. pp. 171–198. ISBN 0077104285.
 Chatfield, C. (1993). "Calculating Interval Forecasts". Journal of Business and Economic Statistics. 11 (2): 121–135. doi:10.1080/07350015.1993.10509938.
 HoTrieu, N. L.; Tucker, J. (1990). "Another note on the use of a logarithmic time trend". Review of Marketing and Agricultural Economics. 58 (1): 89–90.
 Kungl. Vetenskapsakademien (The Royal Swedish Academy of Sciences) (2003). "Timeseries econometrics: Cointegration and autoregressive conditional heteroskedasticity". Advanced information on the Bank of Sweden Prize in Economic Sciences in Memory of Alfred Nobel.
 Arianos, S.; Carbone, A.; Turk, C. (2011). "Selfsimilarity of highorder moving averages". Physical Review E. 84: 046113. doi:10.1103/physreve.84.046113.