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Thioxanthene

From Wikipedia, the free encyclopedia

Thioxanthene
Names
Preferred IUPAC name
9H-Thioxanthene[1]
Other names
10H-Dibenzo[b,e]thiin
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.005.430 Edit this at Wikidata
UNII
  • InChI=1S/C13H10S/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-8H,9H2 checkY
    Key: PQJUJGAVDBINPI-UHFFFAOYSA-N checkY
  • InChI=1/C13H10S/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-8H,9H2
    Key: PQJUJGAVDBINPI-UHFFFAOYAP
  • S2c1ccccc1Cc3c2cccc3
Properties
C13H10S
Molar mass 198.28 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Thioxanthene is a chemical compound in which the oxygen atom in xanthene is replaced with a sulfur atom. It is also related to phenothiazine. Several of its derivatives are used as typical antipsychotics in the treatment of schizophrenia and other psychoses.

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Transcription

Derivatives

The derivatives of thioxanthene used clinically as antipsychotics include:

The therapeutic efficacy of these drugs is related to their ability to antagonize the D2 receptors in the brain, though they have actions at other sites such as serotonin, adrenaline, and histamine receptors as well which mostly contribute to side effects.

The thioxanthenes, as a class, are closely related chemically to the phenothiazines. The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a double bond to the side chain.[2] This difference is noted in the illustration of flupenthixol, which shows a double-bonded carbon in the number 10 position (opposite the sulfur molecule in the central chain).

References

  1. ^ International Union of Pure and Applied Chemistry (2014). Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013. The Royal Society of Chemistry. p. 213. doi:10.1039/9781849733069. ISBN 978-0-85404-182-4.
  2. ^ Goodman & Gilman's The Pharmacological Basis of Therapeutics

External links

This page was last edited on 19 January 2022, at 22:04
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