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Tax gene product

From Wikipedia, the free encyclopedia

A Tax Gene Product (Tax) is a nuclear protein that has a molecular weight of about 37,000 to 40,000 daltons.

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Transcription

Let's think about how a tax on a product might affect it, if the demand for it is very, very, very elastic. So what I've done here -- We're going to think about flags -- the market for a certain type of flag that's made in China. And to think about this flag -- think about it this way. If the price -- the price right now -- the equilibrium price between where the supply and the demand intersect -- the supply curve and the demand curve intersect -- is right about seventy dollars per flag. So this is a pretty nice flag. It's right at seventy dollars per flag. And the quantity demanded, in thousands per year, it looks like it's about twenty five thousand flags are demanded per year. Now if at the price were to go slightly above that equilibrium price,what's going to happen? Well, if the price goes slightly above that equilibrium price, people are going to say, "Well, I can go by the American flags made in Taiwan, or even the ones made in America, or made in Mexico, or made some place else. [Because...] "People won't be able to tell the difference from a distance." So I'm going to buy one of the substitutes -- [because] especially the ones from Taiwan or Mexico or wherever else. are identical to the ones made in China. So if the price for slightly -- even slightly higher, the quantity demanded would be much, much, much lower. And if the price were even a little bit lower, then people say, "I'm not going to buy the Mexican flag-- or the Taiwanese [or] American flags. I'm going to buy the ones that were made in China." And then the quantity demanded would be much larger. And so what you have here is a very large, a high elasticity of demand. So this right over here, this is almost perfectly elastic. If it was perfectly elastic, it would be completely horizontal. So this is almost almost almost perfectly -- perfectly elastic -- elastic demand. A very small change in price leads to a huge change in quantity. In particular a very small percentage change in price leads to a huge percent change in quantity. So let's say that -- that some government official decides, "You know what? [I] don't like the idea of American flags being made in China." So they decide to tax American flags made in China. So what they do is that they place a tax, they place a tax -- And once again I'll do a fixed dollar tax. It could be a percentage and if a percentage then it'll change the sup -- the supply plus tax curve It'll be -- the shift will will be a percentage change instead of a fixed change. But the fixed change is a little bit easier to draw, so I'll do that. So let's say that there is a tax -- Let me do that in a different color Let's say that there's a tax placed of ten dollars -- ten dollars per flag. Ten dollars, actually -- Let's do an even a smaller amount. Let's say that there is a tax placed of of one dollar per flag -- one dollar per flag. I'll make it a little bit larger. Let's say it's five dollars per flag -- five dollars per flag. So now what is the supply plus tax curve? So the supplier / just to make the flags in China and ship them to United States and get the story here even to get that first flag done even if is that in the most efficient way possible looks do you need at least looks like around fifty to fifty three dollars now Now they're going now they're still going to need that plus there's going to be a five dollar tax on it So supply plus tax is going to be that plus five dollars is going to be right around there Over here, you add five dollars. So at any given point, we're gonna add fivedollars to essentially what the consumer would have to see. \\So you would have a curve that looks something like this you would have a curve that looks something like this you would have a curve that looks something like this. That dotted line right over there is our supply is our supply plus tax. This right over here was just our supply --was just our supply. So you're essentially -- So let's think about what happens here. Your equilibrium price was at seventy before. Now our equilibrium price is still -- Our equilibrium price is still pretty much at seventy. But our equilibrium quantity has gone down dramatically. Our equilibrium quantity has gone down to -- our equilibrium quantity has gone down to -- I don't know. It looks like about eighteen thousand. Eighteen thousand flags per year. So who bore -- who bore the bulk of this right over here? So let's think about the tax revenue So the tax revenue in this situation is going to be eighteen thousand times the five dollars. So this is the five dollars right over here. That is five dollars -- and then times eighteen thousand -- times eighteen thousand. So this right over here is the tax revenue. That right over there is a tax revenue. Actually, let me draw a little bit more carefully so the tax revenue is This is going to be between this line right over here and five dollars. So just like that. So that's all the tax revenue. And notice. It all came out of the producer surplus. The original producer surplus -- the original producer surplus was -- Especially if we assume perfect elasticity -- The original producer surplus was this green rectangle plus this and plus this. Now this is going to be -- This little area right over here is going to be dead weight loss -- dead-weight loss. And all of that came from the producer's surplus. And then the all the tax revenue, also -- If you especially if you assume this top-line was horizontal -- also came out of the producer surplus. So in this situation where you had almost where you We could say, if if you do have perfect elasticity if you have perfect elasticity of demand for the product, The person who's going to bear the the brunt of the tax -- so -- is going to be the producer. The producer surplus is going to be eaten into from the tax. Bears -- bears the Actually that's not -- that's not (I'm not talking about the animal, "bears.") The producer, -- You know -- I'm not -- well -- The producer gets the burden the producer The producer gets the burden in that situation. And this is an interesting thing to think about. Because when you have almost perfectly elastic demand -- so a -- almost -- or if you said perfectly elastic demand -- a flat -- a flat demand curve right over here -- there's -- there's actually no consumer surplus, because the marginal benefit, even the incremental marginal or -- (I'm -- I'm being redundant with the words incremental and marginal.) But the marginal benefit at any point for the consumer for -- that -- for that next unit is equal to the price they're paying, when you have -- There's no -- There's -- Especially if the the especially if the demand curve is perfectly elastic -- and it's perfectly horizontal -- There is no area between the demand curve and the price paid. So there's actually -- There's isn't any -- even any consumer surplus to take any -- to take any of the -- to take -- to eat into. It all gets eaten out of the out of the producer surplus.

Tax gene

Tax is produced by members of the retroviral family primate T-lymphotropic virus, which are classified as Deltaretroviruses. This includes Human T-lymphotrophic viruses (HTLVs), bovine leukaemia virus (BLV) and simian T-lymphotropic viruses (STLVs). The tax protein produced from HTLV-1 and HTLV-2 have been most extensively studied.[1] The gene for Tax is found within the pX region between the env gene and one of the long terminal repeats of the viral genome; which is where the name Tax comes from (transactivator from the X-gene region). Tax acts as a transactivator, causing the transcription (production of mRNA from genetic code) of viral proteins in the long terminal repeat that are essential for replication.[2][3][4]

Role in disease

HTLV-1 causes an aggressive form of leukaemia: adult T cell leukaemia (ATL), and Tax has largely been implicated in the oncogenic potential of this virus. In addition to Tax's ability to promote the transcription of viral proteins in the nucleus, it also regulates many human genes. It does this by modulating the activity of several signaling pathways such as: CREB/ATF, NF-κB, AP-1 and SRF.[4] Tax modulates cellular processes by protein-protein interaction (binding with proteins), transcriptional activation (promoting the production of proteins) and transcriptional repression (inhibiting the production of proteins). Cellular processes that Tax dysregulates to produce cancerous cells include the cell cycle and the maintenance of genomic integrity. The cell cycle has four stages (G1, S, G2 and M) and Tax is known to accelerate the transition between G1 and S phase. Two DNA repair pathways (base excision repair and nucleotide excision repair) are affected by Tax, leading to mutations in DNA; a classical hallmark of cancer. Tax also causes aneuploidy (abnormal chromosome numbers), which is a possible cause of transformation (normal cells becoming cancer cells). Many proteins are involved in these processes, including cyclins and cell cycle checkpoint proteins (p53 and Rb).[4] Interesting, HTLV-1 Tax viral gene is known to dampen innate antiviral signaling pathways to avoid host detection and elimination, through SOCS1 and Aryl Hydrocarbon Receptor Interacting Protein (AIP).[5][6]

Although Tax from HTLV-1 and HTLV-2 can cause cells to become cancerous experimentally, Tax produced by HTLV-2 is less oncogenic than that from HTLV-1 and therefore is thought to be the reason that HTLV-2 is not associated with ATL.[1]

References

  1. ^ a b Romanelli, MG; Diani, E; Bergamo, E; Casoli, C; Ciminale, V; Bex, F; Bertazzoni, U (Sep 9, 2013). "Highlights on distinctive structural and functional properties of HTLV Tax proteins". Frontiers in Microbiology. 4: 271. doi:10.3389/fmicb.2013.00271. PMC 3766827. PMID 24058363.
  2. ^ Womack, edited by W. Jean Dodds, James E. (1997). Molecular genetics, gene transfer, and therapy. San Diego, Calif.: Academic Press. ISBN 0120392410. {{cite book}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link)
  3. ^ Ross, TM; Pettiford, SM; Green, PL (Aug 1996). "The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes". Journal of Virology. 70 (8): 5194–202. doi:10.1128/JVI.70.8.5194-5202.1996. PMC 190475. PMID 8764028.
  4. ^ a b c Jeang, KT; Giam, CZ; Majone, F; Aboud, M (Jul 30, 2004). "Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation". The Journal of Biological Chemistry. 279 (31): 31991–4. doi:10.1074/jbc.r400009200. PMID 15090550.
  5. ^ Charoenthongtrakul, Soratree; Zhou, Qinjie; Shembade, Noula; Harhaj, Nicole S.; Harhaj, Edward W. (2011-07-15). "Human T Cell Leukemia Virus Type 1 Tax Inhibits Innate Antiviral Signaling via NF-κB-Dependent Induction of SOCS1". Journal of Virology. 85 (14): 6955–6962. doi:10.1128/JVI.00007-11. ISSN 0022-538X. PMC 3126571. PMID 21593151.
  6. ^ Zhou, Qinjie; Lavorgna, Alfonso; Bowman, Melissa; Hiscott, John; Harhaj, Edward W. (2015-06-05). "Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon". Journal of Biological Chemistry. 290 (23): 14729–14739. doi:10.1074/jbc.M114.633065. ISSN 0021-9258. PMC 4505538. PMID 25911105.
This page was last edited on 16 June 2022, at 01:54
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