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Tasosartan

From Wikipedia, the free encyclopedia

Tasosartan
Clinical data
Pregnancy
category
  • N/A
ATC code
Legal status
Legal status
  • Withdrawn
Identifiers
  • 2,4-dimethyl-8-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H21N7O
Molar mass411.469 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Tasosartan is an angiotensin II receptor antagonist.

It was withdrawn from FDA review by the manufacturer after phase III clinical trials showed elevated transaminases (a sign of possible liver toxicity) in a significant number of participants given the drug.[1][2]

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  • Controlled Drug Delivery ll Biological Factors ll NDDS ll Part IV

Transcription

References

  1. ^ Atkinson AJ, et al. (2007). Principles of clinical pharmacology. Amsterdam: Elsevier. p. 515. ISBN 978-0-12-369417-1.
  2. ^ Dina R, Jafari M (July 2000). "Angiotensin II-receptor antagonists: an overview". Am J Health Syst Pharm. 57 (13): 1231–41. doi:10.1093/ajhp/57.13.1231. PMID 10902066.


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This page was last edited on 9 March 2022, at 22:52
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