TP53RK

TP53RK

Identifiers

TP53RK, BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2, TP53 regulating kinase, GAMOS4, TPRKB

External IDs

OMIM: 608679 MGI: 1914050 HomoloGene: 6042 GeneCards: TP53RK

3.6.-.-

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q13.12	Start	46,684,365 bp^[1]
Band	20q13.12	End	46,689,444 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 H3	Start	166,634,451 bp^[2]
Band	2\|2 H3	End	166,641,425 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

islet of Langerhans

bronchial epithelial cell

stromal cell of endometrium

skin of abdomen

lymph node

smooth muscle tissue

gastrocnemius muscle

palpebral conjunctiva

monocyte

Top expressed in

spermatid

female urethra

primitive streak

yolk sac

neural tube

spermatocyte

morula

trigeminal ganglion

renal corpuscle

motor neuron

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	kinase activity transferase activity nucleotide binding protein kinase activity p53 binding protein binding ATP binding hydrolase activity phosphotransferase activity, alcohol group as acceptor protein serine/threonine kinase activity
Cellular component	cytosol membrane nucleus nucleoplasm EKC/KEOPS complex cytoplasm
Biological process	protein phosphorylation phosphorylation tRNA threonylcarbamoyladenosine metabolic process tRNA processing regulation of signal transduction by p53 class mediator
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


112858


76367

Ensembl


ENSG00000172315


ENSMUSG00000042854

UniProt


Q96S44


Q99PW4

RefSeq (mRNA)


NM_033550


NM_023815

RefSeq (protein)


NP_291028


NP_076304.2

Location (UCSC)

Chr 20: 46.68 – 46.69 Mb

Chr 2: 166.63 – 166.64 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene.^[5]^[6]^[7] This protein is a serine/threonine protein kinase that phosphorylates p53 at Ser15.

PRPK is part of the KEOPS/EKC complex, which participates in transcription control,^[8] telomere regulation ^[9] and tRNA modification.^[10]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172315 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042854 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Abe Y, Matsumoto S, Wei S, Nezu K, Miyoshi A, Kito K, Ueda N, Shigemoto K, Hitsumoto Y, Nikawa J, Enomoto Y (Nov 2001). "Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes". The Journal of Biological Chemistry. 276 (47): 44003–11. doi:10.1074/jbc.M105669200. PMID 11546806.
^ Facchin S, Lopreiato R, Ruzzene M, Marin O, Sartori G, Götz C, Montenarh M, Carignani G, Pinna LA (Aug 2003). "Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency". FEBS Letters. 549 (1–3): 63–6. doi:10.1016/S0014-5793(03)00770-1. PMID 12914926. S2CID 24581860.
^ "Entrez Gene: TP53RK TP53 regulating kinase".
^ Kisseleva-Romanova E, Lopreiato R, Baudin-Baillieu A, Rousselle JC, Ilan L, Hofmann K, Namane A, Mann C, Libri D (Aug 2006). "Yeast homolog of a cancer-testis antigen defines a new transcription complex". The EMBO Journal. 25 (15): 3576–85. doi:10.1038/sj.emboj.7601235. PMC 1538566. PMID 16874308.
^ Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D (Mar 2006). "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator". Cell. 124 (6): 1155–68. doi:10.1016/j.cell.2005.12.044. PMID 16564010. S2CID 13928061.
^ Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin EV, Karzai AW, Sternglanz R (Mar 2011). "The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A". The EMBO Journal. 30 (5): 873–81. doi:10.1038/emboj.2010.343. PMC 3049205. PMID 21183954.

Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N (Apr 2003). "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein". Biochemical and Biophysical Research Communications. 303 (2): 399–405. doi:10.1016/S0006-291X(03)00333-4. PMID 12659830.
Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC (Sep 2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2". Cancer Cell. 6 (3): 251–61. doi:10.1016/j.ccr.2004.07.012. PMID 15380516.
Abe Y, Takeuchi T, Imai Y, Murase R, Kamei Y, Fujibuchi T, Matsumoto S, Ueda N, Ogasawara M, Shigemoto K, Kito K (May 2006). "A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK". Biochemical and Biophysical Research Communications. 344 (1): 377–85. doi:10.1016/j.bbrc.2006.03.071. PMID 16600182.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 28 November 2023, at 16:57

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References

Further reading