TFEC

TFEC

Identifiers

TFEC, TCFEC, TFE-C, TFEC-L, TFECL, bHLHe34, hTFEC-L, transcription factor EC

External IDs

OMIM: 604732 MGI: 1333760 HomoloGene: 32148 GeneCards: TFEC

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q31.2	Start	115,935,148 bp^[1]
Band	7q31.2	End	116,159,896 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 A2	Start	16,833,372 bp^[2]
Band	6\|6 A2	End	16,898,440 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

monocyte

appendix

kidney tubule

bone marrow cells

spleen

lymph node

jejunal mucosa

upper lobe of left lung

right lung

Achilles tendon

Top expressed in

proximal tubule

kidney

yolk sac

morula

spleen

ileum

left lung lobe

calvaria

dermis

iris

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA-binding transcription factor activity DNA binding transcription coactivator activity protein binding protein dimerization activity transcription corepressor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	nucleus nucleoplasm
Biological process	cellular response to heat regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of nucleic acid-templated transcription transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


22797


21426

Ensembl


ENSG00000105967


ENSMUSG00000029553

UniProt


O14948


Q9WTW4

RefSeq (mRNA)


NM_001018058 NM_001244583 NM_012252


NM_031198

RefSeq (protein)


NP_001018068 NP_001231512 NP_036384


NP_112475

Location (UCSC)

Chr 7: 115.94 – 116.16 Mb

Chr 6: 16.83 – 16.9 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Transcription factor EC is a protein that in humans is encoded by the TFEC gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105967 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029553 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yasumoto K, Shibahara S (Aug 1997). "Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator". Biochim Biophys Acta. 1353 (1): 23–31. doi:10.1016/s0167-4781(97)00034-1. PMID 9256061.
^ "Entrez Gene: TFEC transcription factor EC".

Zhao GQ, Zhao Q, Zhou X, et al. (1993). "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation". Mol. Cell. Biol. 13 (8): 4505–12. doi:10.1128/mcb.13.8.4505. PMC 360062. PMID 8336698.
Steingrímsson E, Tessarollo L, Reid SW, et al. (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization". Development. 125 (23): 4607–16. doi:10.1242/dev.125.23.4607. PMID 9806910.
Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells". Biochemistry. 40 (30): 8887–97. doi:10.1021/bi002847d. PMID 11467950.
Mansky KC, Sulzbacher S, Purdom G, et al. (2002). "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter". J. Leukoc. Biol. 71 (2): 304–10. doi:10.1189/jlb.71.2.304. PMID 11818452. S2CID 22801820.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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This page was last edited on 14 August 2023, at 23:01

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References

Further reading