TAF15

TAF15
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2MMY
Identifiers
Aliases	TAF15, Npl3, RBP56, TAF2N, TAFII68, TATA-box binding protein associated factor 15
External IDs	OMIM: 601574 MGI: 1917689 HomoloGene: 131088 GeneCards: TAF15
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 35,809,482 bp[1] End 35,864,615 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 83,473,086 bp[2] End 83,506,743 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endometrium ganglionic eminence monocyte lymph node zone of skin skin of abdomen gastric mucosa anterior pituitary right uterine tube appendix Top expressed in yolk sac aortic valve ascending aorta esophagus superior frontal gyrus lip secondary oocyte mirror thymus masseter muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding RNA binding Cellular component cytoplasm nucleolus nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8148 70439 Ensembl ENSG00000270647 ENSG00000276833 ENSMUSG00000020680 UniProt Q92804 n/a RefSeq (mRNA) NM_003487 NM_139215 NM_027427 RefSeq (protein) NP_003478 NP_631961 n/a Location (UCSC) Chr 17: 35.81 – 35.86 Mb Chr 11: 83.47 – 83.51 Mb PubMed search [3] [4]
Wikidata
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TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.^[5][6][7]

Function

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.^[7]

Interactions

TAF15 has been shown to interact with:

References

Further reading

External links

• Overview of all the structural information available in the PDB for UniProt: Q92804 (TATA-binding protein-associated factor 2N) at the PDBe-KB.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

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This page was last edited on 13 August 2023, at 21:58