Micellar solubilization (solubilization) is the process of incorporating the solubilizate (the component that undergoes solubilization) into or onto micelles.[1] Solubilization may occur in a system consisting of a solvent, an association colloid (a colloid that forms micelles), and at least one other solubilizate.
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Micellar solubilization and hydrotrophy
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Micellar Solubilization (CHE )
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solubilization & Detergency || L-8 Unit-3 || Physical Pharmaceutics
Transcription
Usage of the term
Solubilization is distinct from dissolution because the resulting fluid is a colloidal dispersion involving an association colloid. This suspension is distinct from a true solution, and the amount of the solubilizate in the micellar system can be different (often higher) than the regular solubility of the solubilizate in the solvent.
In non-chemical literature and in everyday language, the term "solubilization" is sometimes used[citation needed] in a broader meaning as "to bring to a solution or (non-sedimenting) suspension" by any means, e.g., leaching by a reaction with an acid.
Application
Micellar solubilization is widely utilized, e.g. in laundry washing using detergents, in the pharmaceutical industry, for formulations of poorly soluble drugs in solution form,[2] and in cleanup of oil spills using dispersants.
Mechanism
Literature distinguishes two major mechanisms of solubilization process of oil by surfactant micelles, affecting the kinetics of solubilization:[3] surface reaction, i.e., by transient adsorption of micelles at the water-oil interface, and bulk reaction, whereby the surfactant micelles capture dissolved oil molecules.
See also
References
- ^ "micellar solubilization". The IUPAC Compendium of Chemical Terminology. 2009. doi:10.1351/goldbook.M03887.
- ^ Jain A, Ran Y, Yalkowsky S, "Effect of pH-Sodium Lauryl Sulfate Combination on Solubilization of PG-300995 (an Anti-HIV Agent): A Technical Note." AAPS PharmSciTech. 2004; 5(3): article 45. [1]
- ^ P. D. Todorov, P. A. Kralchevsky, N. D. Denkov, G. Broze, and A. Mehreteab, "Kinetics of Solubilization of n-Decane and Benzene by Micellar Solutions of Sodium Dodecyl Sulfate". Journal of Colloid and Interface Science 245, 371–382 (2002), doi:10.1006/jcis.2001.8031 [2]
External links
Solubilization of Homopolymers by Block Copolymer Micelles in Dilute Solutions, J. Phys. Chem., 1995, 99 (11), pp 3723–3731, Jose R. Quintana, Ramiro A. Salazar, Issa Katime
This page was last edited on 6 April 2024, at 16:46