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Solasulfone

From Wikipedia, the free encyclopedia

Solasulfone
Names
IUPAC name
Tetrasodium 3,3'-[sulfonylbis(benzene-4,1-diylimino)]bis(1-phenylpropane-1,3-disulfonate)
Other names
Solapsone; Sulfetrone
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.004.652 Edit this at Wikidata
UNII
  • InChI=1S/C30H32N2O14S5.4Na/c33-47(34,25-15-11-23(12-16-25)31-29(50(41,42)43)19-27(48(35,36)37)21-7-3-1-4-8-21)26-17-13-24(14-18-26)32-30(51(44,45)46)20-28(49(38,39)40)22-9-5-2-6-10-22;;;;/h1-18,27-32H,19-20H2,(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46);;;;/q;4*+1/p-4
  • [Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C(c1ccccc1)CC(Nc2ccc(cc2)S(=O)(=O)c4ccc(NC(S([O-])(=O)=O)CC(c3ccccc3)S([O-])(=O)=O)cc4)S([O-])(=O)=O
Properties
C30H28N2Na4O14S5
Molar mass 892.81 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Solasulfone is an antileprotic drug developed from the parent compound sulphetrone.[1] It was first described and evaluated in the 1930s and 1940s as an antibacterial agent for the treatment of tuberculosis and various other infections, and later found to be effective in the treatment of leprosy.[2]

References

  1. ^ Chemistry for Pharmacy and the Life Sciences (1996, Pearson Education Limited) Thomas, Gareth; ppg. 349-350
  2. ^ Brownlee, George; Green, A. F.; Woodbine, M. (March 1948). "Sulphetrone*: A Chemotherapeutic Agent for Tuberculosis: Pharmacology and Chemotherapy". British Journal of Pharmacology and Chemotherapy. 3 (1): 15–28. doi:10.1111/j.1476-5381.1948.tb00348.x. PMC 1509804. PMID 18904720.


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This page was last edited on 24 January 2024, at 15:08
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