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Solasonine

From Wikipedia, the free encyclopedia

Solasonine
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ECHA InfoCard 100.038.917 Edit this at Wikidata
UNII
  • Key: QCTMYNGDIBTNSK-XEAAVONHSA-N
  • C[C@@H]1CC[C@@]2(NC1)O[C@H]3C[C@H]4[C@@H]5CC=C6C[C@H](CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C)O[C@@H]7O[C@H](CO)[C@H](O)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]7O[C@@H]9O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O
Properties
C
45H
73NO
16
Molar mass 884.07 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Solasonine is a glycoalkaloid that is found in Solanum plants of the family Solanaceae.[1] Solasonine is a poisonous chemical compound when used at high levels. It is a glycoside of solasodine. Glycoalkaloids such as Solasonine have various applications including pharmacology, cancer treatments and even a role as a pesticide.

High levels of glycoalkaloids are toxic to humans due to their ability to disrupt cell-membrane function.[2] There is a loss of membrane integrity which puts the cell at risk for apoptosis (cell death) due to the ability of any chemical coming into contact with the cell.

Solasonine was one component of the unsuccessful experimental cancer drug candidate Coramsine.

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Transcription

Side Effects

Although, solasonine has anti-infection properties it has many adverse side effects as a steroidal glycoalkaloid.[3] These side effects include low blood pressure, a decrease in respiratory activity, rapid heart beat etc.[3] These side effects are the direct result of the cytotoxic properties of solasonine (at high levels) that lead to disrupted cell membranes.

See also

References

  1. ^ Everist, S.L. (1981). Poisonous Plants of Australia. Angus & Robertson. ISBN 0-207-14228-9.
  2. ^ Al Sinani, S.S.S.; Eltayeb, E.A. (September 2017). "The steroidal glycoalkaloids solamargine and solasonine in Solanum plants". South African Journal of Botany. 112: 253–269. doi:10.1016/j.sajb.2017.06.002. ISSN 0254-6299.
  3. ^ a b Yang, Jun; Huang, Wenjing; Tan, Wenfu (2016). "Solasonine, A Natural Glycoalkaloid Compound, Inhibits Gli-Mediated Transcriptional Activity". Molecules. 21 (10): 1364. doi:10.3390/molecules21101364. PMC 6274431. PMID 27754442.

External links


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This page was last edited on 24 January 2024, at 15:08
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