Serine hydroxymethyltransferase 2

SHMT2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3OU5, 4PVF

Identifiers

Aliases

SHMT2, GLYA, HEL-S-51e, SHMT, serine hydroxymethyltransferase 2, NEDCASB

External IDs

OMIM: 138450; MGI: 1277989; HomoloGene: 133984; GeneCards: SHMT2; OMA:SHMT2 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.3	Start	57,229,573 bp^[1]
Band	12q13.3	End	57,234,935 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 D3	Start	127,352,992 bp^[2]
Band	10\|10 D3	End	127,358,313 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lobe of liver

oocyte

stromal cell of endometrium

secondary oocyte

embryo

body of pancreas

tibia

ganglionic eminence

parotid gland

lymph node

Top expressed in

left lobe of liver

condyle

kidney

yolk sac

proximal tubule

internal carotid artery

somite

calvaria

fossa

external carotid artery

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity amino acid binding chromatin binding L-allo-threonine aldolase activity protein binding catalytic activity identical protein binding glycine hydroxymethyltransferase activity pyridoxal phosphate binding zinc ion binding cobalt ion binding serine binding
Cellular component	membrane BRISC complex microtubule cytoskeleton mitochondrial intermembrane space extracellular exosome mitochondrial inner membrane cytoplasm mitochondrion mitochondrial matrix mitochondrial nucleoid nucleus
Biological process	L-serine biosynthetic process tetrahydrofolate interconversion protein tetramerization tetrahydrofolate metabolic process protein K63-linked deubiquitination folic acid metabolic process glycine biosynthetic process from serine response to type I interferon positive regulation of cell population proliferation glycine biosynthetic process protein homotetramerization one-carbon metabolic process glycine metabolic process L-serine metabolic process regulation of oxidative phosphorylation L-serine catabolic process regulation of mitochondrial translation regulation of aerobic respiration cellular response to tetrahydrofolate
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6472


108037

Ensembl


ENSG00000182199


ENSMUSG00000025403

UniProt


P34897


Q9CZN7

RefSeq (mRNA)


NM_001166356 NM_001166357 NM_001166358 NM_001166359 NM_005412


NM_001252316 NM_028230

RefSeq (protein)


NP_001159828 NP_001159829 NP_001159830 NP_001159831 NP_005403


NP_001239245 NP_082506

Location (UCSC)

Chr 12: 57.23 – 57.23 Mb

Chr 10: 127.35 – 127.36 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serine hydroxymethyltransferase 2 is an enzyme that in humans is encoded by the SHMT2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182199 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025403 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Anderson DD, Stover PJ (June 2009). "SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis". PLOS ONE. 4 (6): e5839. Bibcode:2009PLoSO...4.5839A. doi:10.1371/journal.pone.0005839. PMC 2688753. PMID 19513116.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 4 March 2023, at 01:11

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References