SPOCK2

SPOCK2

Identifiers

SPOCK2, testican-2, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2

External IDs

OMIM: 607988 MGI: 1891351 HomoloGene: 8854 GeneCards: SPOCK2

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q22.1	Start	72,059,034 bp^[1]
Band	10q22.1	End	72,089,032 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 B4	Start	59,942,041 bp^[2]
Band	10\|10 B4	End	59,971,020 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 10

spinal ganglia

cerebellar vermis

middle frontal gyrus

superior vestibular nucleus

pons

inferior olivary nucleus

external globus pallidus

nucleus accumbens

ventral tegmental area

Top expressed in

habenula

entorhinal cortex

dorsomedial hypothalamic nucleus

superior colliculus

medial dorsal nucleus

subiculum

dorsal tegmental nucleus

medulla oblongata

lateral geniculate nucleus

inferior colliculus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium ion binding glycosaminoglycan binding extracellular matrix binding metalloendopeptidase inhibitor activity collagen binding
Cellular component	extracellular region extracellular matrix extracellular space
Biological process	regulation of cell differentiation synapse assembly peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan extracellular matrix organization signal transduction positive regulation of cell-substrate adhesion negative regulation of endopeptidase activity positive regulation of cell motility cellular response to leukemia inhibitory factor
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9806


94214

Ensembl


ENSG00000107742


ENSMUSG00000058297

UniProt


Q92563


Q9ER58

RefSeq (mRNA)


NM_001134434 NM_001244950 NM_014767


NM_052994

RefSeq (protein)


NP_001127906 NP_001231879 NP_055582


NP_443720

Location (UCSC)

Chr 10: 72.06 – 72.09 Mb

Chr 10: 59.94 – 59.97 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Testican-2 is a protein that in humans is encoded by the SPOCK2 gene.^[5]^[6]

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Transcription

Function

Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, are components of the extracellular matrix. SPOCK2 encodes a member of a novel Ca(2+)-binding proteoglycan family.[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107742 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058297 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vannahme C, Schübel S, Herud M, Gösling S, Hülsmann H, Paulsson M, Hartmann U, Maurer P (July 1999). "Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain". Journal of Neurochemistry. 73 (1): 12–20. doi:10.1046/j.1471-4159.1999.0730012.x. PMID 10386950. S2CID 21955542.
^ ^a ^b "Entrez Gene: SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2".

Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. CiteSeerX 10.1.1.319.3770. doi:10.1093/dnares/3.5.321. PMID 9039502.
Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Nakada M, Miyamori H, Yamashita J, Sato H (June 2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins". Cancer Research. 63 (12): 3364–9. PMID 12810672.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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This page was last edited on 25 February 2024, at 13:45

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Transcription

Function

References

Further reading