SPOCK1

SPOCK1
Identifiers
Aliases	SPOCK1, SPOCK, TESTICAN, TIC1, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
External IDs	OMIM: 602264 MGI: 105371 HomoloGene: 80193 GeneCards: SPOCK1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 136,975,298 bp[1] End 137,598,379 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 57,569,008 bp[2] End 58,056,146 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium postcentral gyrus Brodmann area 46 orbitofrontal cortex cerebellar cortex cerebellar hemisphere superior frontal gyrus entorhinal cortex inferior olivary nucleus pons Top expressed in medial dorsal nucleus medial geniculate nucleus superior frontal gyrus olfactory epithelium cerebellar cortex anterior horn of spinal cord lateral geniculate nucleus primary motor cortex prefrontal cortex dorsomedial hypothalamic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding cysteine-type endopeptidase inhibitor activity metalloendopeptidase inhibitor activity serine-type endopeptidase inhibitor activity collagen binding extracellular matrix binding Cellular component cytoplasm postsynaptic density neuromuscular junction node of Ranvier extracellular region sarcoplasm extracellular space Biological process negative regulation of cell-substrate adhesion neurogenesis negative regulation of neuron projection development neuron migration nervous system development cell adhesion regulation of cell growth central nervous system neuron differentiation signal transduction negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6695 20745 Ensembl ENSG00000152377 ENSMUSG00000056222 UniProt Q08629 Q62288 RefSeq (mRNA) NM_004598 NM_001166463 NM_001166464 NM_001166465 NM_001166466 NM_009262 RefSeq (protein) NP_004589 n/a Location (UCSC) Chr 5: 136.98 – 137.6 Mb Chr 13: 57.57 – 58.06 Mb PubMed search [3] [4]
Wikidata
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Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.^[5][6]

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.^[6]

References

Further reading

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This page was last edited on 7 February 2024, at 21:15