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Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10gene.[5][6] Siglec-G is often referred to as the murine paralog of human Siglec-10 [7]
Structure and function
Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab.[8] It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).
Gene family summary
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM][6]
Yousef GM, Ordon MH, Foussias G, Diamandis EP (2001). "Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants". Biochem. Biophys. Res. Commun. 284 (4): 900–10. doi:10.1006/bbrc.2001.5053. PMID11409878.
Nagano T, Yoneda T, Hatanaka Y, et al. (2002). "Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone". Nat. Cell Biol. 4 (7): 495–501. doi:10.1038/ncb808. PMID12055638. S2CID4795393.
Kitzig F, Martinez-Barriocanal A, López-Botet M, Sayós J (2002). "Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1". Biochem. Biophys. Res. Commun. 296 (2): 355–62. doi:10.1016/S0006-291X(02)00885-9. PMID12163025.
This page was last edited on 3 December 2023, at 02:28