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From Wikipedia, the free encyclopedia

IUPAC name
Other names
3D model (JSmol)
  • 4470639 aldehydo form D-(−)-Ribose No
ECHA InfoCard 100.000.055
EC Number 200-059-4
Molar mass 150.13 g/mol
Appearance white solid
Melting point 95 °C (203 °F; 368 K)
100 g/1 L (25 °C (77 °F))
−21.5° (H2O)
Related compounds
Related aldopentoses
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
No verify (what is YesYNo ?)
Infobox references

Ribose is a carbohydrate with the formula C5H10O5; specifically, it is a pentose monosaccharide (simple sugar) with linear form H−(C=O)−(CHOH)4−H, which has all the hydroxyl groups on the same side in the Fischer projection.

The term may refer to either of two enantiomers. The term usually indicates D-ribose, which occurs widely in nature and is discussed here. Its synthetic mirror image, L-ribose, is not found in nature.

D-Ribose was first reported in 1891 by Emil Fischer.[citation needed] It is a C'-2 carbon epimer of the sugar D-arabinose (both isomers of which are named for their source, gum arabic) and ribose itself is named as a partial rearrangement of letters in the word 'arabinose'.[3]

The ribose β-D-ribofuranose forms part of the backbone of RNA. It is related to deoxyribose, which is found in DNA. Phosphorylated derivatives of ribose such as ATP and NADH play central roles in metabolism. cAMP and cGMP, formed from ATP and GTP, serve as secondary messengers in some signalling pathways.


Ribose is an aldopentose (a monosaccharide containing five carbon atoms) that, in its open chain form, has an aldehyde functional group at one end. In the conventional numbering scheme for monosaccharides, the carbon atoms are numbered from C1' (in the aldehyde group) to C5'. The deoxyribose derivative found in DNA differs from ribose by having a hydrogen atom in place of the hydroxyl group at C2'. This hydroxyl group performs a function in RNA splicing.

Like many monosaccharides, ribose exists in an equilibrium among 5 forms—the linear form H−(C=O)−(CHOH)4–H and either of the two ring forms: alpha- or beta-ribofuranose (“C3'-endo”), with a five-membered ring, and alpha- or beta-ribopyranose (“C2'-endo”), with a six-membered ring. The beta-ribopyranose form predominates in aqueous solution.[4]

The “D-” in the name D-ribose refers to the stereochemistry of the chiral carbon atom farthest away from the aldehyde group (C4'). In D-ribose, as in all D-sugars, this carbon atom has the same configuration as in D-glyceraldehyde.

Relative abundance of different forms of ribose in solution: β-D-ribopyranose (59%), α-D-ribopyranose (20%), β-D-ribofuranose (13%), α-D-ribofuranose (7%) and open chain (0.1%).[5]


In biology, D-ribose must be phosphorylated by the cell before it can be used. Ribokinase catalyzes this reaction by converting D-ribose to D-ribose 5-phosphate. Once converted, D-ribose-5-phosphate is available for the manufacturing of the amino acids tryptophan and histidine, or for use in the pentose phosphate pathway. The absorption of D-ribose is 88–100% in the small intestines (up to 200 mg/kg/h).[6]

Medical uses

D-ribose has been suggested for use in management of congestive heart failure[7] (as well as other forms of heart disease) and for chronic fatigue syndrome (CFS), also called myalgic encephalomyelitis (ME).[8]


  1. ^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th ed.), Merck, 1989, ISBN 091191028X , 8205
  2. ^ Weast, Robert C., ed. (1981). CRC Handbook of Chemistry and Physics (62nd ed.). Boca Raton, FL: CRC Press. p. C-506. ISBN 0-8493-0462-8. 
  3. ^ Nechamkin, Howard (December 1958). "Some interesting etymological derivations of chemical terminology". Science Education. 42 (5): 463–474. doi:10.1002/sce.3730420523. 
  4. ^ Angyal, S. J. (March 1969). "The Composition and Conformation of Sugars in Solution". Angewandte Chemie. 8 (3): 157–166. doi:10.1002/anie.196901571. Retrieved 5 June 2012. 
  5. ^ Drew, Kenneth N.; Zajicek, Jaroslav; Bondo, Gail; Bose, Bidisha; Serianni, Anthony S. (February 1998). "13C-labeled aldopentoses: detection and quantitation of cyclic and acyclic forms by heteronuclear 1D and 2D NMR spectroscopy". Carbohydrate Research. 307 (3–4): 199–209. doi:10.1016/S0008-6215(98)00040-8. Retrieved 11 December 2014. 
  6. ^ "Herbal Remedies, Supplements A-Z Index". PDRHealth. Archived from the original on 11 October 2008. 
  7. ^ Omran, Heyder; McCarter, Dean; St Cyr, John; Lüderitz, Berndt (2004). "D-ribose aids congestive heart failure patients". Experimental & Clinical Cardiology. Summer (9(2)): 117–118. PMC 2716264Freely accessible. PMID 19641697. 
  8. ^ Teitelbaum,, Jacob E.; Johnson, Clarence; St Cyr, John (2006-11-26). "The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study". The Journal of Alternative and Complementary Medicine. 12 (9): 857–862. doi:10.1089/acm.2006.12.857. PMID 17109576. 

This page was last edited on 15 July 2018, at 18:14
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