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From Wikipedia, the free encyclopedia

D-Ribose
Names
IUPAC name
(2S,3R,4S,5R)-5-(hydroxymethyl)oxolane-2,3,4-triol
Other names
D-Ribose
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • 4470639 aldehydo form D-(−)-Ribose ☒N
DrugBank
ECHA InfoCard 100.000.055
EC Number 200-059-4
Properties[1][2]
C5H10O5
Molar mass 150.13 g/mol
Appearance white solid
Melting point 95 °C (203 °F; 368 K)
100 g/1 L (25 °C (77 °F))
−21.5° (H2O)
Related compounds
Related aldopentoses
Arabinose
Xylose
Lyxose
Related compounds
Deoxyribose
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is ☑Y☒N ?)
Infobox references

Ribose is a carbohydrate with the formula C5H10O5; specifically, it is a pentose monosaccharide (simple sugar) with linear form H−(C=O)−(CHOH)4−H, which has all the hydroxyl groups on the same side in the Fischer projection.

The term may refer to either of two enantiomers. The term usually indicates D-ribose, which occurs widely in nature and is discussed here. Its synthetic mirror image, L-ribose, is not found in nature.

D-Ribose was first reported in 1891 by Emil Fischer.[citation needed] It is a C'-2 carbon epimer of the sugar D-arabinose (both isomers of which are named for their source, gum arabic) and ribose itself is named as a partial rearrangement of letters in the word 'arabinose'.[3]

The ribose β-D-ribofuranose forms part of the backbone of RNA. It is related to deoxyribose, which is found in DNA. Phosphorylated derivatives of ribose such as ATP and NADH play central roles in metabolism. cAMP and cGMP, formed from ATP and GTP, serve as secondary messengers in some signalling pathways.

YouTube Encyclopedic

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  • D-Ribose
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  • 3.2.2 Identify amino acids, glucose, ribose and fatty acids from diagrams showing their structure
  • D-Ribose and Energy (Update: See our other videos on PEMF therapy)

Transcription

Good morning ladies! It is 8:30 on a Saturday morning and I am ready to go. I have full energy. I love it and I want to thank, thank, thank my naturopathic doctor for this uh... I was getting the typical 2:00 lull where I felt like I was dragging, but even before that I would get up and hit the floor. Get ready to start my day. I would make breakfast and I would have energy. Then 5 minutes... ten minutes...30 minutes later I was dragging again and on my way to work I was like, "gosh I need a coffee" or I need green tea or some sort of energy boost. Later, because of that, i wanted to have some more energy so i would want to have energy drinks but I tried my hardest not to have any of that stuff. I would try to push myself through the day and it felt awful. It's the worst feeling I personally can experience, When I am struggling to just keep my eyes open and make it through my work day. no one should live like that. You shouldn't live like that. so i went to my naturopath to get an overall health consultation and one thing that found out was about my energy. I realized that one thing that i am possibly lacking is this thing called D-ribose. D-R-I-B-O-S-E it is a natural amino acid so there is no fake stuff or chemicals pumped into your blood stream that is making you have super fake energy. your heart dosen't race, you don't get anxiety. It is outstanding! I love it! i'm so excited about it, so i will share with you because i want you to it the same benefits and feel that energy that I have been missing for years so this stuff is great. I do have to tell you when you do you get a it, it's a little pricey. It is in the $40's, but when you get a look for this one thing called Corvalen. It must have Corvalen in it. So don't just get any D-ribose its C-O-R V-A-L-E-N Corvalen! This is amazing. It's in a powder. You can get is in powder or tab form... tablet form I put a little scoop once, it says you can do it twice, but I do it once a day i stir it up with water and it's really sweet and its actually kinda yummy so i'm really really excited about this product uh... cool thing is that with this it only took about two weeks, I was still drinking green tea I still wanted something that first week or so and then all a sudden, lightbulb! I felt my head wasn't foggy, fuzziness. I could think clearly. I was driving to work and I was actually awake attuned with everything around me. I wasn't gunna crash into anyone I felt normal as weird as that sounds to say I felt normal, but I felt normal. I finally had that normal energy that you expect your body to naturally have so this is a lifesaver for me. I now live by it and I am telling my family and friends about it. I want you to have the same energy that crave about without all that junk and all those chemicals and all that harsh toxins on your body. So, ditch the monster and try this just for uh... a month and see how you feel and I promis, promise promise u you will notice a difference in your overall energy and overall health. so I am super excited about this. I hope you all enjoy it! This is actually a little bit about it. I don't know if I went into it. It is an amino acid, makes ATP whatever you eat it stores or uses as energy and so before this i've thought my ATP was on vacation or my little ATP guys were retired, i don't know. But this is a miracle for me so go online and look it up. You could get on Ebay, they sell it in the store so financial ground get the best deal. Don't uh... invest too much money in it. Just make sure it says Corvalen and it is D-ribose and you are set. I hope you enjoy this blog. I hope it really helps you. and if you get it please let me know . Comment in a couple of weeks. Or whenever you start feeling it and let me know cause I would love to hear some feedback from you. You have a good one and remember to RESET YOUR MINDSET.

Contents

Structure

Ribose is an aldopentose (a monosaccharide containing five carbon atoms) that, in its open chain form, has an aldehyde functional group at one end. In the conventional numbering scheme for monosaccharides, the carbon atoms are numbered from C1' (in the aldehyde group) to C5'. The deoxyribose derivative found in DNA differs from ribose by having a hydrogen atom in place of the hydroxyl group at C2'. This hydroxyl group performs a function in RNA splicing.

Like many monosaccharides, ribose exists in an equilibrium among 5 forms—the linear form H−(C=O)−(CHOH)4–H and either of the two ring forms: alpha- or beta-ribofuranose (“C3'-endo”), with a five-membered ring, and alpha- or beta-ribopyranose (“C2'-endo”), with a six-membered ring. The beta-ribopyranose form predominates in aqueous solution.[4]

The “D-” in the name D-ribose refers to the stereochemistry of the chiral carbon atom farthest away from the aldehyde group (C4'). In D-ribose, as in all D-sugars, this carbon atom has the same configuration as in D-glyceraldehyde.

Relative abundance of different forms of ribose in solution: β-D-ribopyranose (59%), α-D-ribopyranose (20%), β-D-ribofuranose (13%), α-D-ribofuranose (7%) and open chain (0.1%).[5]

Phosphorylation

In biology, D-ribose must be phosphorylated by the cell before it can be used. Ribokinase catalyzes this reaction by converting D-ribose to D-ribose 5-phosphate. Once converted, D-ribose-5-phosphate is available for the manufacturing of the amino acids tryptophan and histidine, or for use in the pentose phosphate pathway. The absorption of D-ribose is 88–100% in the small intestines (up to 200 mg/kg/h).[6]

Medical uses

D-ribose has been suggested for use in management of congestive heart failure[7] (as well as other forms of heart disease) and for chronic fatigue syndrome (CFS), also called myalgic encephalomyelitis (ME).[8]

References

  1. ^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (11th ed.), Merck, 1989, ISBN 091191028X , 8205
  2. ^ Weast, Robert C., ed. (1981). CRC Handbook of Chemistry and Physics (62nd ed.). Boca Raton, FL: CRC Press. p. C-506. ISBN 0-8493-0462-8. 
  3. ^ Nechamkin, Howard (December 1958). "Some interesting etymological derivations of chemical terminology". Science Education. 42 (5): 463–474. doi:10.1002/sce.3730420523. 
  4. ^ Angyal, S. J. (March 1969). "The Composition and Conformation of Sugars in Solution". Angewandte Chemie. 8 (3): 157–166. doi:10.1002/anie.196901571. Retrieved 5 June 2012. 
  5. ^ Drew, Kenneth N.; Zajicek, Jaroslav; Bondo, Gail; Bose, Bidisha; Serianni, Anthony S. (February 1998). "13C-labeled aldopentoses: detection and quantitation of cyclic and acyclic forms by heteronuclear 1D and 2D NMR spectroscopy". Carbohydrate Research. 307 (3–4): 199–209. doi:10.1016/S0008-6215(98)00040-8. Retrieved 11 December 2014. 
  6. ^ "Herbal Remedies, Supplements A-Z Index". PDRHealth. Archived from the original on 11 October 2008. 
  7. ^ Omran, Heyder; McCarter, Dean; St Cyr, John; Lüderitz, Berndt (2004). "D-ribose aids congestive heart failure patients". Experimental & Clinical Cardiology. Summer (9(2)): 117–118. PMC 2716264Freely accessible. PMID 19641697. 
  8. ^ Teitelbaum,, Jacob E.; Johnson, Clarence; St Cyr, John (2006-11-26). "The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study". The Journal of Alternative and Complementary Medicine. 12 (9): 857–862. doi:10.1089/acm.2006.12.857. PMID 17109576. 

This page was last edited on 15 July 2018, at 18:14
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