RUFY1

RUFY1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2YQM, 2YW8

Identifiers

Aliases

RUFY1, RABIP4, ZFYVE12, RUN and FYVE domain containing 1

External IDs

OMIM: 610327; MGI: 2429762; HomoloGene: 23522; GeneCards: RUFY1; OMA:RUFY1 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q35.3	Start	179,550,554 bp^[1]
Band	5q35.3	End	179,610,012 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 B1.3	Start	50,280,113 bp^[2]
Band	11\|11 B1.3	End	50,321,952 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

monocyte

Achilles tendon

sural nerve

corpus callosum

blood

right uterine tube

gastric mucosa

right lung

spleen

skin of abdomen

Top expressed in

proximal tubule

retinal pigment epithelium

secondary oocyte

seminal vesicula

interventricular septum

superior frontal gyrus

temporal muscle

triceps brachii muscle

adrenal gland

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding metal ion binding lipid binding SH3 domain binding SH2 domain binding
Cellular component	intracellular membrane-bounded organelle membrane cytoplasm cytosol nuclear speck early endosome membrane endosome nucleus
Biological process	protein transport endocytosis phosphatidylinositol biosynthetic process regulation of endocytosis small GTPase mediated signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


80230


216724

Ensembl


ENSG00000284260 ENSG00000176783


ENSMUSG00000020375

UniProt


Q96T51


Q8BIJ7

RefSeq (mRNA)


NM_001040451 NM_001040452 NM_025158


NM_172557

RefSeq (protein)


NP_001035541 NP_001035542 NP_079434


NP_766145

Location (UCSC)

Chr 5: 179.55 – 179.61 Mb

Chr 11: 50.28 – 50.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene.^[5]^[6] It is named after the RUN and FYVE domains it contains.

Interactions

RUFY1 has been shown to interact with BMX.^[5]

References

^ ^a ^b ^c ENSG00000176783 GRCh38: Ensembl release 89: ENSG00000284260, ENSG00000176783 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020375 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Yang J, Kim O, Wu J, Qiu Y (Aug 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.
^ "Entrez Gene: RUFY1 RUN and FYVE domain containing 1".

Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y (2001). "A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1637–42. doi:10.1073/pnas.031586998. PMC 29309. PMID 11172003.
Fouraux MA, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij WJ, van der Sluijs P, Pruijn GJ (2004). "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes". Mol. Biol. Cell. 15 (2): 611–24. doi:10.1091/mbc.E03-05-0343. PMC 329268. PMID 14617813.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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This page was last edited on 14 June 2023, at 21:06

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Interactions

References

Further reading