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RABEPK

From Wikipedia, the free encyclopedia

RABEPK
Identifiers
AliasesRABEPK, RAB9P40, bA65N13.1, p40, Rab9 effector protein with kelch motifs
External IDsOMIM: 605962 MGI: 2139530 HomoloGene: 48772 GeneCards: RABEPK
Orthologs
SpeciesHumanMouse
Entrez

10244

227746

Ensembl

ENSG00000136933

ENSMUSG00000070953

UniProt

Q7Z6M1
Q5T1S5

Q8VCH5

RefSeq (mRNA)

NM_001174152
NM_001174153
NM_005833

NM_145522
NM_001374669

RefSeq (protein)

NP_001167623
NP_001167624
NP_005824

NP_663497
NP_001361598

Location (UCSC)Chr 9: 125.2 – 125.23 MbChr 2: 34.67 – 34.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rab9 effector protein with Kelch motifs also known as p40 is a protein that in humans is encoded by the RABEPK gene.[5][6]

Membrane-associated p40, in together with RAB9A, facilitates the transport of the mannose 6-phosphate receptor (MPR) from endosomes to the trans-Golgi network.[5]

Interactions

RABEPK has been shown to interact with RAB9A[5] and FYVE finger-containing phosphoinositide kinase.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136933 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070953 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Diaz E, Schimmoller F, Pfeffer SR (Aug 1997). "A novel Rab9 effector required for endosome-to-TGN transport". J Cell Biol. 138 (2): 283–90. doi:10.1083/jcb.138.2.283. PMC 2138197. PMID 9230071.
  6. ^ "Entrez Gene: RABEPK Rab9 effector protein with kelch motifs".
  7. ^ Ikonomov, Ognian C; Sbrissa Diego; Mlak Krzysztof; Deeb Robert; Fligger Jason; Soans Aleric; Finley Russell L; Shisheva Assia (Dec 2003). "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40". J. Biol. Chem. 278 (51): 50863–71. doi:10.1074/jbc.M307260200. ISSN 0021-9258. PMID 14530284.

Further reading

External links


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This page was last edited on 28 March 2022, at 02:29
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