Pyridoxine 4-dehydrogenase

In enzymology, a pyridoxine 4-dehydrogenase (EC 1.1.1.65) is an enzyme that catalyzes the chemical reaction

pyridoxine + NADP⁺ ${\displaystyle \rightleftharpoons }$ pyridoxal + NADPH + H⁺

Thus, the two substrates of this enzyme are pyridoxine and NADP⁺, whereas its 3 products are pyridoxal, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donors with NAD⁺ or NADP⁺ as acceptors. The systematic name of this enzyme class is pyridoxine:NADP⁺ 4-oxidoreductase. Other names in common use include pyridoxin dehydrogenase, pyridoxol dehydrogenase, and pyridoxine dehydrogenase. This enzyme participates in vitamin B₆ metabolism.

References

• Holzer H, Schneider S (1961). "[Purification and characterization of a TPN-dependent pyridoxol dehydrogenase from brewers yeast.]". Biochim. Biophys. Acta (in German). 48: 71–6. doi:10.1016/0006-3002(61)90516-9. PMID 13715611.

This page was last edited on 1 June 2024, at 13:28