Precorrin-6Y C5,15-methyltransferase (decarboxylating)

In enzymology, a precorrin-6Y C5,15-methyltransferase (decarboxylating) (EC 2.1.1.132) is an enzyme that catalyzes the chemical reaction

2 S-adenosyl-L-methionine + precorrin-6Y ${\displaystyle \rightleftharpoons }$ 2 S-adenosyl-L-homocysteine + precorrin-8X + CO₂

The two substrates of this enzyme are S-adenosyl methionine and precorrin 6Y; its three products are S-adenosylhomocysteine, precorrin 8X, and CO₂.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating). Other names in common use include precorrin-6 methyltransferase, precorrin-6Y methylase and CobL. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in aerobic bacteria.

See also

• Cobalamin biosynthesis

References

• Blanche F, Famechon A, Thibaut D, Debussche L, Cameron B, Crouzet J (1992). "Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6y to precorrin-8x is catalyzed by the cobL gene product". J. Bacteriol. 174 (3): 1050–2. PMC 206191. PMID 1732195.

This page was last edited on 26 August 2023, at 15:31