Phenylalanine 2-monooxygenase

In enzymology, a phenylalanine 2-monooxygenase (EC 1.13.12.9) is an enzyme that catalyzes the chemical reaction

L-phenylalanine + O₂ ${\displaystyle \rightleftharpoons }$ 2-phenylacetamide + CO₂ + H₂O

Thus, the two substrates of this enzyme are L-phenylalanine and O₂, whereas its 3 products are 2-phenylacetamide, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating). Other names in common use include L-phenylalanine oxidase (deaminating and decarboxylating), and phenylalanine (deaminating, decarboxylating)oxidase. This enzyme participates in phenylalanine metabolism.

References

• Koyama H (October 1982). "Purification and characterization of a novel L-phenylalanine oxidase (Deaminating and decarboxylating) from Pseudomonas sp. P-501". J. Biochem. Tokyo. 92 (4): 1235–40. PMID 7174643.
• Koyama H (August 1984). "Oxidation and oxygenation of L-amino acids catalyzed by a L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501". J. Biochem. Tokyo. 96 (2): 421–7. PMID 6501250.
• Koyama H (1984). "A simple and rapid enzymatic determination of L-phenylalanine with a novel L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501". Clin. Chim. Acta. 136 (2–3): 131–6. doi:10.1016/0009-8981(84)90284-5. PMID 6692570.
• Koyama H, Suzuki H (October 1986). "Spectral and kinetic studies on Pseudomonas L-phenylalanine oxidase (deaminating and decarboxylating)". J. Biochem. Tokyo. 100 (4): 859–66. PMID 3818566.

This page was last edited on 26 August 2023, at 15:20