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Pharmacokinetics simulation

From Wikipedia, the free encyclopedia

Pharmacokinetics simulation is a simulation method used in determining the safety levels of a drug during its development.

Purpose

Pharmacokinetics simulation gives an insight to drug efficacy and safety before exposure of individuals to the new drug that might help to improve the design of a clinical trial. Pharmacokinetics simulations help in addition in therapy planning, to stay within the therapeutic range under various physiological and pathophysiological conditions, e.g., chronic kidney disease.

Simulators

Simcyp Simulator and GastroPlus (from Simulations Plus) are simulators that take account for individual variabilities. PharmaCalc v02 and PharmaCalcCL allow to simulate individual plasma-concentration time curves based on (published) pharmacokinetic parameters such as half-life, volume of distribution etc.


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This page was last edited on 15 July 2022, at 22:08
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