PRB4

PRB4

Identifiers

PRB4, Po, proline-rich protein BstNI subfamily 4, proline rich protein BstNI subfamily 4

External IDs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12p13.2	Start	11,307,077 bp^[1]
Band	12p13.2	End	11,310,436 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

thymus

bone marrow

liver

urinary bladder

skin of abdomen

blood

lymph node

lung

islet of Langerhans

spleen

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	molecular function
Cellular component	extracellular region
Biological process	biological process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5545


n/a

Ensembl


ENSG00000274839 ENSG00000230657


n/a

UniProt


P10163


n/a

RefSeq (mRNA)


NM_002723 NM_001261399


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr 12: 11.31 – 11.31 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene.^[3]

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.^[3]

PRB4 is post-translationally cleaved into three different mature peptides:

Protein N1
Glycosylated protein A
Peptide P-D (also known as proline-rich peptide IB-5)

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References

^ ^a ^b ^c ENSG00000230657 GRCh38: Ensembl release 89: ENSG00000274839, ENSG00000230657 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4".

Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 1. Vol. 17. pp. 141–199. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. PMID 3055850.
Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092. S2CID 31373141.
Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC 1203497. PMID 2851479.
Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi:10.1016/S0021-9258(17)39156-1. PMID 2993301.
Lyons KM, Azen EA, Goodman PA, Smithies O (1989). "Many Protein Products from a Few Loci: Assignment of Human Salivary Proline-Rich Proteins to Specific Loci". Genetics. 120 (1): 255–65. doi:10.1093/genetics/120.1.255. PMC 1203496. PMID 3220251.
Warner TF, Azen EA (1984). "Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract". Am. Rev. Respir. Dis. 130 (1): 115–8. doi:10.1164/arrd.1984.130.1.115 (inactive 31 January 2024). PMID 6377992.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link)
Saitoh E, Isemura S, Sanada K (1983). "Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva". J. Biochem. 93 (2): 495–502. doi:10.1093/jb/93.3.883. PMID 6841349.
Kauffman DL, Keller PJ, Bennick A, Blum M (1993). "Alignment of amino acid and DNA sequences of human proline-rich proteins". Crit. Rev. Oral Biol. Med. 4 (3–4): 287–92. doi:10.1177/10454411930040030501. PMID 8373986.
Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499. S2CID 24058984.
Azen EA, Amberger E, Fisher S, et al. (1996). "PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins". Am. J. Hum. Genet. 58 (1): 143–53. PMC 1914931. PMID 8554050.
Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC 25286. PMID 9487127.
Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vallat JM, Magy L, Lagrange E, et al. (2007). "Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance". Acta Neuropathol. 113 (4): 443–9. doi:10.1007/s00401-007-0196-7. PMID 17294201. S2CID 42561185.

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