PPP5C

PPP5C

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1A17, 1S95, 1WAO, 2BUG, 3H60, 3H61, 3H62, 3H63, 3H64, 3H66, 3H67, 3H68, 3H69, 4ZX2, 4ZVZ

Identifiers

Aliases

PPP5C, PP5, PPP5, PPT, protein phosphatase 5 catalytic subunit

External IDs

OMIM: 600658 MGI: 102666 HomoloGene: 4550 GeneCards: PPP5C

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.32	Start	46,347,087 bp^[1]
Band	19q13.32	End	46,392,981 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7 A2\|7 9.15 cM	Start	16,738,565 bp^[2]
Band	7 A2\|7 9.15 cM	End	16,761,849 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

ganglionic eminence

anterior pituitary

stromal cell of endometrium

right adrenal gland

left adrenal gland

gastric mucosa

right lobe of thyroid gland

body of stomach

transverse colon

Top expressed in

yolk sac

superior frontal gyrus

cerebellar cortex

somite

neural tube

primitive streak

stomach

right ventricle

submandibular gland

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	phosphoprotein phosphatase activity heat shock protein binding microtubule binding ADP binding protein serine/threonine phosphatase activity signal transducer activity metal ion binding protein binding RNA binding identical protein binding G-protein alpha-subunit binding hydrolase activity ATP binding lipid binding Hsp90 protein binding
Cellular component	perikaryon membrane intracellular membrane-bounded organelle plasma membrane neuronal cell body proximal dendrite neuron projection nucleus cell periphery nucleoplasm cytoplasm cytosol
Biological process	negative regulation of protein phosphorylation positive regulation of glucocorticoid receptor signaling pathway protein heterooligomerization protein dephosphorylation negative regulation of cell death cellular response to cadmium ion transcription, DNA-templated MAPK cascade cellular response to DNA damage stimulus response to morphine response to lead ion protein complex oligomerization positive regulation of I-kappaB kinase/NF-kappaB signaling cellular response to hydrogen peroxide negative regulation of neuron death DNA repair mitotic cell cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5536


19060

Ensembl


ENSG00000011485


ENSMUSG00000003099

UniProt


P53041


Q60676

RefSeq (mRNA)


NM_006247 NM_001204284


NM_011155

RefSeq (protein)


NP_001191213 NP_006238


NP_035285

Location (UCSC)

Chr 19: 46.35 – 46.39 Mb

Chr 7: 16.74 – 16.76 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene.^[5]^[6]

Interactions

PPP5C has been shown to interact with ASK1,^[7] CRY2^[8] GNA12.^[9] and Rac1,^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011485 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003099 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yong WH, Ueki K, Chou D, Reeves SA, von Deimling A, Gusella JF, Mohrenweiser HW, Buckler AJ, Louis DN (Sep 1995). "Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3". Genomics. 29 (2): 533–6. doi:10.1006/geno.1995.9972. PMID 8666404.
^ "Entrez Gene: PPP5C Protein phosphatase 5, catalytic subunit".
^ Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov 2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". The EMBO Journal. 20 (21): 6028–36. doi:10.1093/emboj/20.21.6028. PMC 125685. PMID 11689443.
^ Zhao S, Sancar A (Nov 1997). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity". Photochemistry and Photobiology. 66 (5): 727–31. doi:10.1111/j.1751-1097.1997.tb03214.x. PMID 9383998. S2CID 32804361.
^ Yamaguchi Y, Katoh H, Mori K, Negishi M (Aug 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367. S2CID 11485795.
^ Chatterjee A, Wang L, Armstrong DL, Rossie S (Feb 2010). "Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro". The Journal of Biological Chemistry. 285 (6): 3872–82. doi:10.1074/jbc.M109.088427. PMC 2823530. PMID 19948726.

Chen MX, McPartlin AE, Brown L, Chen YH, Barker HM, Cohen PT (Sep 1994). "A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus". The EMBO Journal. 13 (18): 4278–90. doi:10.1002/j.1460-2075.1994.tb06748.x. PMC 395355. PMID 7925273.
Skinner J, Sinclair C, Romeo C, Armstrong D, Charbonneau H, Rossie S (Sep 1997). "Purification of a fatty acid-stimulated protein-serine/threonine phosphatase from bovine brain and its identification as a homolog of protein phosphatase 5". The Journal of Biological Chemistry. 272 (36): 22464–71. doi:10.1074/jbc.272.36.22464. PMID 9278397.
Shah BH, Catt KJ (Dec 2006). "Protein phosphatase 5 as a negative key regulator of Raf-1 activation". Trends in Endocrinology and Metabolism. 17 (10): 382–4. doi:10.1016/j.tem.2006.10.013. PMID 17084641. S2CID 45060016.
Goedert M, Cohen ES, Jakes R, Cohen P (Nov 1992). "p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]". FEBS Letters. 312 (1): 95–9. doi:10.1016/0014-5793(92)81418-L. PMID 1330687. S2CID 34940651.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Xu X, Lagercrantz J, Zickert P, Bajalica-Lagercrantz S, Zetterberg A (Jan 1996). "Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene". Biochemical and Biophysical Research Communications. 218 (2): 514–7. doi:10.1006/bbrc.1996.0092. PMID 8561788.
Silverstein AM, Galigniana MD, Chen MS, Owens-Grillo JK, Chinkers M, Pratt WB (Jun 1997). "Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin". The Journal of Biological Chemistry. 272 (26): 16224–30. doi:10.1074/jbc.272.26.16224. PMID 9195923.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhao S, Sancar A (Nov 1997). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity". Photochemistry and Photobiology. 66 (5): 727–31. doi:10.1111/j.1751-1097.1997.tb03214.x. PMID 9383998. S2CID 32804361.
Ollendorff V, Donoghue DJ (Dec 1997). "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex". The Journal of Biological Chemistry. 272 (51): 32011–8. doi:10.1074/jbc.272.51.32011. PMID 9405394.
Das AK, Cohen PW, Barford D (Mar 1998). "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions". The EMBO Journal. 17 (5): 1192–9. doi:10.1093/emboj/17.5.1192. PMC 1170467. PMID 9482716.
Russell LC, Whitt SR, Chen MS, Chinkers M (Jul 1999). "Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90". The Journal of Biological Chemistry. 274 (29): 20060–3. doi:10.1074/jbc.274.29.20060. PMID 10400612.
Lubert EJ, Hong Y, Sarge KD (Oct 2001). "Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5". The Journal of Biological Chemistry. 276 (42): 38582–7. doi:10.1074/jbc.M106906200. PMID 11504734.
Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov 2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". The EMBO Journal. 20 (21): 6028–36. doi:10.1093/emboj/20.21.6028. PMC 125685. PMID 11689443.
Sanchez-Ortiz E, Hahm BK, Armstrong DL, Rossie S (Oct 2009). "Protein phosphatase 5 protects neurons against amyloid-beta toxicity". Journal of Neurochemistry. 111 (2): 391–402. doi:10.1111/j.1471-4159.2009.06337.x. PMC 3044491. PMID 19686245.
Yamaguchi Y, Katoh H, Mori K, Negishi M (Aug 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367. S2CID 11485795.
Gentile S, Darden T, Erxleben C, Romeo C, Russo A, Martin N, Rossie S, Armstrong DL (Mar 2006). "Rac GTPase signaling through the PP5 protein phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 103 (13): 5202–6. Bibcode:2006PNAS..103.5202G. doi:10.1073/pnas.0600080103. PMC 1458818. PMID 16549782.
Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX (2003). "Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5". Neuroscience. 115 (3): 829–37. doi:10.1016/S0306-4522(02)00510-9. PMID 12435421. S2CID 26118803.
Urban G, Golden T, Aragon IV, Cowsert L, Cooper SR, Dean NM, Honkanen RE (Mar 2003). "Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression". The Journal of Biological Chemistry. 278 (11): 9747–53. doi:10.1074/jbc.M210993200. PMID 12519780.
Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.

v t e PDB gallery
1a17: TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5 1s95: Structure of serine/threonine protein phosphatase 5 1wao: PP5 STRUCTURE 2bug: SOLUTION STRUCTURE OF THE TPR DOMAIN FROM PROTEIN PHOSPHATASE 5 IN COMPLEX WITH HSP90 DERIVED PEPTIDE

This page was last edited on 19 December 2023, at 02:52

From Wikipedia, the free encyclopedia

Interactions

References

Further reading