PPIL1

PPIL1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1XWN, 2K7N, 2X7K

Identifiers

Aliases

PPIL1, CYPL1, PPIase, hCyPX, CGI-124, peptidylprolyl isomerase like 1, PCH14

External IDs

OMIM: 601301 MGI: 1916066 HomoloGene: 9367 GeneCards: PPIL1

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.2	Start	36,854,827 bp^[1]
Band	6p21.2	End	36,874,803 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 A3.3	Start	29,469,777 bp^[2]
Band	17\|17 A3.3	End	29,483,160 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right ventricle

oocyte

secondary oocyte

left adrenal gland

islet of Langerhans

ganglionic eminence

prefrontal cortex

sperm

nucleus accumbens

metanephros

Top expressed in

superior cervical ganglion

morula

neural tube

yolk sac

renal corpuscle

hand

endocardial cushion

interventricular septum

primitive streak

abdominal wall

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	isomerase activity protein binding disordered domain specific binding peptidyl-prolyl cis-trans isomerase activity cyclosporin A binding
Cellular component	catalytic step 2 spliceosome spliceosomal complex nucleoplasm nucleus U2-type catalytic step 2 spliceosome
Biological process	mRNA processing protein folding RNA splicing mRNA splicing, via spliceosome protein peptidyl-prolyl isomerization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51645


68816

Ensembl


ENSG00000137168


ENSMUSG00000024007

UniProt


Q9Y3C6


Q9D0W5

RefSeq (mRNA)


NM_016059


NM_026845

RefSeq (protein)


NP_057143


NP_081121

Location (UCSC)

Chr 6: 36.85 – 36.87 Mb

Chr 17: 29.47 – 29.48 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 1 is an enzyme that in humans is encoded by the PPIL1 gene.^[5]^[6]^[7]

This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.

Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137168 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024007 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mann SS, Pettenati MJ, von Kap-herr C, Hart TC (Mar 1999). "Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 228–9. doi:10.1159/000015186. PMID 10072585. S2CID 85413695.
^ Ozaki K, Fujiwara T, Kawai A, Shimizu F, Takami S, Okuno S, Takeda S, Shimada Y, Nagata M, Watanabe T, Takaichi A, Takahashi E, Nakamura Y, Shin S (Jan 1997). "Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet. 72 (2–3): 242–5. doi:10.1159/000134199. PMID 8978786.
^ ^a ^b "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1".

Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Xu C, Xu Y, Tang Y, et al. (2005). "Backbone and side chain assignments of human Peptidylprolyl Isomerase Like 1 (hPPIL1)". J. Biomol. NMR. 31 (2): 179–80. doi:10.1007/s10858-004-8238-0. PMID 15772761. S2CID 30456850.
Xu C, Zhang J, Huang X, et al. (2006). "Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP". J. Biol. Chem. 281 (23): 15900–8. doi:10.1074/jbc.M511155200. PMID 16595688.

v t e PDB gallery
1xwn: solution structure of cyclophilin like 1(PPIL1) and insights into its interaction with SKIP

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This page was last edited on 3 March 2023, at 23:30

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References

Further reading