PIP5K1A

PIP5K1A

Identifiers

PIP5K1A, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

External IDs

OMIM: 603275 MGI: 107929 HomoloGene: 93492 GeneCards: PIP5K1A

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q21.3	Start	151,197,949 bp^[1]
Band	1q21.3	End	151,249,536 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F2.1	Start	95,058,530 bp^[2]
Band	3\|3 F2.1	End	95,106,930 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

Achilles tendon

gastric mucosa

left uterine tube

skin of abdomen

islet of Langerhans

canal of the cervix

gallbladder

anterior pituitary

left lobe of thyroid gland

Top expressed in

olfactory tubercle

cumulus cell

dentate gyrus

pineal gland

primary motor cortex

nucleus accumbens

amygdala

hippocampus proper

calvaria

belly cord

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding 1-phosphatidylinositol-4-phosphate 5-kinase activity kinase activity kinase binding protein binding phosphatidylinositol phosphate kinase activity ATP binding 1-phosphatidylinositol-3-phosphate 5-kinase activity 1-phosphatidylinositol-5-kinase activity phosphatidylinositol-3,4-bisphosphate 5-kinase activity 1-phosphatidylinositol-3-phosphate 4-kinase activity
Cellular component	nuclear speck mRNA cleavage and polyadenylation specificity factor complex cell projection membrane focal adhesion ruffle plasma membrane nucleoplasm ruffle membrane nucleus lamellipodium cytoplasm cytosol
Biological process	fibroblast migration actin cytoskeleton reorganization phosphatidylinositol metabolic process activation of GTPase activity phosphorylation keratinocyte differentiation focal adhesion assembly phospholipid biosynthetic process phagocytosis cell chemotaxis glycerophospholipid metabolic process ruffle assembly cell migration signal transduction phosphatidylinositol phosphate biosynthetic process regulation of phosphatidylinositol 3-kinase signaling phosphatidylinositol biosynthetic process protein localization to plasma membrane
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8394


18720

Ensembl


ENSG00000143398


ENSMUSG00000028126

UniProt


Q99755


P70182

RefSeq (mRNA)


NM_001135636 NM_001135637 NM_001135638 NM_003557 NM_001330689


NM_001293707 NM_008847

RefSeq (protein)


NP_001129108 NP_001129109 NP_001129110 NP_001317618 NP_003548


NP_001280636 NP_032873

Location (UCSC)

Chr 1: 151.2 – 151.25 Mb

Chr 3: 95.06 – 95.11 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143398 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028126 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Loijens JC, Anderson RA (Jan 1997). "Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family". J Biol Chem. 271 (51): 32937–43. doi:10.1074/jbc.271.51.32937. PMID 8955136.
^ Xie Y, Zhu L, Zhao G (Jun 2000). "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization". Cytogenet Cell Genet. 88 (3–4): 197–9. doi:10.1159/000015545. PMID 10828584. S2CID 45527362.
^ "Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha".

Honda A, Nogami M, Yokozeki T, et al. (1999). "Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation". Cell. 99 (5): 521–32. doi:10.1016/S0092-8674(00)81540-8. PMID 10589680. S2CID 10031591.
Jones DH, Morris JB, Morgan CP, et al. (2000). "Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment". J. Biol. Chem. 275 (18): 13962–6. doi:10.1074/jbc.C901019199. PMID 10747863.
Divecha N, Roefs M, Halstead JR, et al. (2000). "Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity". EMBO J. 19 (20): 5440–9. doi:10.1093/emboj/19.20.5440. PMC 314009. PMID 11032811.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Doughman RL, Firestone AJ, Wojtasiak ML, et al. (2003). "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling". J. Biol. Chem. 278 (25): 23036–45. doi:10.1074/jbc.M211397200. PMID 12682053.
Chang JD, Field SJ, Rameh LE, et al. (2004). "Identification and characterization of a phosphoinositide phosphate kinase homolog". J. Biol. Chem. 279 (12): 11672–9. doi:10.1074/jbc.M309721200. PMID 14701839.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kisseleva M, Feng Y, Ward M, et al. (2005). "The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha". Mol. Cell. Biol. 25 (10): 3956–66. doi:10.1128/MCB.25.10.3956-3966.2005. PMC 1087706. PMID 15870270.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Halstead JR, van Rheenen J, Snel MH, et al. (2006). "A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis". Curr. Biol. 16 (18): 1850–6. doi:10.1016/j.cub.2006.07.066. PMID 16979564. S2CID 15282445.
Im YJ, Perera IY, Brglez I, et al. (2007). "Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum". Plant Cell. 19 (5): 1603–16. doi:10.1105/tpc.107.051367. PMC 1913725. PMID 17496116.

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This page was last edited on 11 October 2022, at 16:53

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References

Further reading