Oxoglutarate dehydrogenase (NADP+)

In enzymology, an oxoglutarate dehydrogenase (NADP+) (EC 1.2.1.52) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate + CoA + NADP⁺ ${\displaystyle \rightleftharpoons }$ succinyl-CoA + CO₂ + NADPH

The 3 substrates of this enzyme are 2-oxoglutarate, CoA, and NADP⁺, whereas its 3 products are succinyl-CoA, CO₂, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating). This enzyme is also called oxoglutarate dehydrogenase (NADP+).

References

• Inui H, Miyatake K, Nakano Y, Kitaoka S (September 1984). "Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis". J. Biochem. Tokyo. 96 (3): 931–4. doi:10.1093/oxfordjournals.jbchem.a134913. PMID 6438078.

This page was last edited on 26 August 2023, at 15:16