 | |
| Clinical data | |
|---|---|
| Trade names | Syncro-Mate B, Crestar |
| Other names | Norgestamet; SC-21009; 11β-Methyl-17α-acetoxy-19-norprogesterone; 17α-Hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate |
| Drug class | Progestogen; Progestin; Progestogen ester |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ECHA InfoCard | 100.042.359 |
| Chemical and physical data | |
| Formula | C23H32O4 |
| Molar mass | 372.505 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Norgestomet, or norgestamet, sold under the brand name Syncro-Mate B and Crestar, is a progestin medication which is used in veterinary medicine to control estrus and ovulation in cattle.[1][2]
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Transcription
Uses
Veterinary
Norgestomet is used in veterinary medicine.
Pharmacology
Pharmacodynamics
Norgestomet is a progestogen. In addition to the progesterone receptor, it possesses weak (micromolar) affinity for the glucocorticoid receptor.[3]
Chemistry
Norgestomet, also known as 11β-methyl-17α-acetoxy-19-norprogesterone or as 17α-hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate, is a synthetic norpregnane steroid and a derivative of progesterone.[1][4]
History
Norgestomet was developed and introduced for veterinary use in the mid-1970s.[5]
Society and culture
Generic names
Norgestomet is the generic name of the drug and its INN, USAN, and BAN.[1][4] It also known as norgestamet and is known by its developmental code name SC-21009.[1][4][6]
Brand names
Norgestomet is marketed under the brand names Syncro-Mate B and Crestar.[1][4]
References
- ^ a b c d e Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 887–. ISBN 978-1-4757-2085-3.
- ^ Favero RJ, Henderson EA, Kesler DJ (1 July 1990). "The Ability of Norgesomet Impregnated Poly(dimethylsiloxane) to Maintain Pregnancy Subsequent to Ovarietomy". In Gebelein CG, Dunn RL (eds.). Progress in Biomedical Polymers. Springer Science & Business Media. pp. 356–. ISBN 978-0-306-43523-2.
- ^ Moffatt RJ, Zollers WG, Welshons WV, Kieborz KR, Garverick HA, Smith MF (January 1993). "Basis of norgestomet action as a progestogen in cattle". Domestic Animal Endocrinology. 10 (1): 21–30. doi:10.1016/0739-7240(93)90005-v. PMID 8467644.
- ^ a b c d "Norgestomet". Drugs.com. Archived from the original on 28 February 2018.
- ^ Gordon U (22 October 2013). "Artificial Control O Oestrus and Ovulation". Controlled Breeding in Farm Animals. Elsevier. pp. 40–. ISBN 978-1-4832-8569-6.
- ^ Houghton PL (1979). "Effect of time of insemination and calf removal after estrus synchronization in beef cattle".
This page was last edited on 26 December 2023, at 18:30