There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).
Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant.[1]
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Neurokinin-1 Receptor Antagonists in CINV
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Pharmacology (Unit=3rd)B.pharma =5th semester. In Hindi
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Transcription
Binding
The genes and receptor ligands are as follows:[2]
| Receptor | Gene | Preferred ligand |
| NK1 | TACR1 | substance P |
| NK2 | TACR2 | neurokinin A |
| NK3 | TACR3 | neurokinin B |
(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
See also
References
- ^ "Aprepitant". NICE. Retrieved 2020-05-10.
- ^ Maggi CA (September 1995). "The mammalian tachykinin receptors". General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.
External links
- "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Tachykinin+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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This page was last edited on 27 August 2022, at 08:42