NDUFS5

NDUFS5

Identifiers

NDUFS5, CI-15k, CI15K, NADH:ubiquinone oxidoreductase subunit S5

External IDs

OMIM: 603847 HomoloGene: 134294 GeneCards: NDUFS5

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p34.3	Start	39,026,318 bp^[1]
Band	1p34.3	End	39,034,636 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left ventricle

optic nerve

Brodmann area 9

nucleus accumbens

caudate nucleus

anterior pituitary

prefrontal cortex

amygdala

cingulate gyrus

gastrocnemius muscle

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity
Cellular component	mitochondrial inner membrane mitochondrial respiratory chain complex I mitochondrial intermembrane space respirasome membrane mitochondrion
Biological process	mitochondrial respiratory chain complex I assembly mitochondrial electron transport, NADH to ubiquinone
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4725


n/a

Ensembl


ENSG00000168653


n/a

UniProt


O43920


n/a

RefSeq (mRNA)


NM_004552 NM_001184979


n/a

RefSeq (protein)


NP_001171908 NP_004543


n/a

Location (UCSC)

Chr 1: 39.03 – 39.03 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 is an enzyme that in humans is encoded by the NDUFS5 gene.^[3]^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168653 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet. 82 (1–2): 115–9. doi:10.1159/000015082. PMID 9763677. S2CID 46818955.
^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
^ "Entrez Gene: NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)".

Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
Loeffen J, Smeets R, Smeitink J, et al. (1999). "The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients". J. Inherit. Metab. Dis. 22 (1): 19–28. doi:10.1023/A:1005434912463. PMID 10070614. S2CID 22326357.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Triepels RH, Hanson BJ, van den Heuvel LP, et al. (2001). "Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns". J. Biol. Chem. 276 (12): 8892–7. doi:10.1074/jbc.M009903200. hdl:2066/185667. PMID 11112787.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Huang G, Chen Y, Lu H, Cao X (2007). "Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death". Cell Death Differ. 14 (2): 327–37. doi:10.1038/sj.cdd.4402004. PMID 16826196.

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This page was last edited on 15 August 2023, at 21:18

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References

Further reading