NAV1

NAV1

Identifiers

NAV1, POMFIL3, STEERIN1, UNC53H1, neuron navigator 1

External IDs

OMIM: 611628 MGI: 2183683 HomoloGene: 10719 GeneCards: NAV1

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q32.1	Start	201,622,885 bp^[1]
Band	1q32.1	End	201,826,969 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 E4	Start	135,362,318 bp^[2]
Band	1\|1 E4	End	135,615,843 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

external globus pallidus

saphenous vein

Brodmann area 23

middle temporal gyrus

inferior ganglion of vagus nerve

pericardium

synovial joint

medulla oblongata

ventral tegmental area

Top expressed in

internal carotid artery

external carotid artery

ventromedial nucleus

vas deferens

subiculum

ganglionic eminence

otolith organ

utricle

olfactory bulb

substantia nigra

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	cytoplasm microtubule cytoskeleton microtubule cytoskeleton axon initial segment
Biological process	multicellular organism development cell differentiation neuron migration microtubule bundle formation nervous system development neurogenesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


89796


215690

Ensembl


ENSG00000134369


ENSMUSG00000009418

UniProt


Q8NEY1


Q8CH77

RefSeq (mRNA)


NM_001167738 NM_020443


NM_173437

RefSeq (protein)


NP_001161210 NP_065176


NP_775613

Location (UCSC)

Chr 1: 201.62 – 201.83 Mb

Chr 1: 135.36 – 135.62 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Neuron navigator 1 is a protein that in humans is encoded by the NAV1 gene.^[5]^[6]^[7]

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134369 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009418 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maes T, Barcelo A, Buesa C (Jun 2002). "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans". Genomics. 80 (1): 21–30. doi:10.1006/geno.2002.6799. PMID 12079279.
^ Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A (Jun 2002). "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms". Gene. 290 (1–2): 73–94. doi:10.1016/S0378-1119(02)00567-X. PMID 12062803.
^ ^a ^b "Entrez Gene: NAV1 neuron navigator 1".

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Peeters PJ, Baker A, Goris I, et al. (2004). "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53". Brain Res. Dev. Brain Res. 150 (2): 89–101. doi:10.1016/j.devbrainres.2004.03.004. PMID 15158073.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Okazaki N, Kikuno R, Ohara R, et al. (2003). "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries". DNA Res. 10 (1): 35–48. doi:10.1093/dnares/10.1.35. PMID 12693553.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.

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This page was last edited on 11 October 2022, at 16:30

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References

Further reading